LCP2

GENE INFORMATION

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Gene name

LCP2 (HGNC Symbol)

Synonyms

SLP-76, SLP76

Description

lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) (HGNC Symbol)

Entrez gene summary

SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. The SLP-76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice. The human and murine cDNAs both encode 533 amino acid proteins that are 72% identical and comprised of three modular domains. The NH2-terminus contains an acidic region that includes a PEST domain and several tyrosine residues which are phosphorylated following TCR ligation. SLP-76 also contains a central proline-rich domain and a COOH-terminal SH2 domain. A number of additional proteins have been identified that associate with SLP-76 both constitutively and inducibly following receptor ligation, supporting the notion that SLP-76 functions as an adaptor or scaffold protein. Studies using SLP-76 deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function. [provided by RefSeq, Jul 2008]

Chromosome

5 (Chromosome progress)

Cytoband

q35.1

Chromosome location (bp)

169673241 - 169725231

Ensembl

ENSG00000043462 (version 73.37)

Entrez gene

3937

UniProt

Q13094 (UniProt - Evidence at protein level)

neXtProt

NX_Q13094

Antibodypedia

LCP2 antibodies
 

PROTEIN VIEW

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LCP2-001
 
LCP2-005
 
LCP2-011
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

LCP2-001 ENSP00000046794
ENST00000046794
Q13094
Show all »
Show » Show » 533 60.2 No 0
LCP2-005 ENSP00000428871
ENST00000521416
E7ESF6
Show all »
Show » Show » 328 36.8 No 0
LCP2-011 ENSP00000430391
ENST00000520344
E5RKA2
Show all »
140 15.6 No 0