CTPS2

GENE INFORMATION

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Gene name

CTPS2

Synonyms

Description

CTP synthase 2 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene catalyzes the formation of CTP from UTP with the concomitant deamination of glutamine to glutamate. This protein is the rate-limiting enzyme in the synthesis of cytosine nucleotides, which play an important role in various metabolic processes and provide the precursors necessary for the synthesis of RNA and DNA. Cancer cells that exhibit increased cell proliferation also exhibit an increased activity of this encoded protein. Thus, this protein is an attractive target for selective chemotherapy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Chromosome

X (Chromosome progress)

Cytoband

p22.2

Chromosome location (bp)

16606126 - 16731059

Ensembl

ENSG00000047230 (version 73.37)

Entrez gene

56474

UniProt

Q9NRF8 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NRF8

Antibodypedia

CTPS2 antibodies
 

PROTEIN VIEW

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CTPS2-001
 
CTPS2-002
 
CTPS2-004
 
CTPS2-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CTPS2-001 ENSP00000369590
ENST00000380241
Q9NRF8
Show all »
Show » Show » 586 65.7 No 0
CTPS2-002 ENSP00000352222
ENST00000359276
Q9NRF8
Show all »
Show » Show » 586 65.7 No 0
CTPS2-004 ENSP00000400431
ENST00000455276
Show » 132 14.5 No 0
CTPS2-201 ENSP00000401264
ENST00000443824
Q9NRF8
Show all »
Show » Show » 586 65.7 No 0