The Human Protein Atlas

GENE INFORMATION

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Gene name	BCAR1 (HGNC Symbol)
Synonyms	CAS, CASS1, Crkas, P130Cas
Description	breast cancer anti-estrogen resistance 1 (HGNC Symbol)
Entrez gene summary	BCAR1, or CAS, is an Src (MIM 190090) family kinase substrate involved in various cellular events, including migration, survival, transformation, and invasion (Sawada et al., 2006 [PubMed 17129785]).[supplied by OMIM, May 2009]
Chromosome	16 (Chromosome progress)
Cytoband	q23.1
Chromosome location (bp)	75262928 - 75301951
Ensembl	ENSG00000050820 (version 69.37)
Entrez gene	9564
UniProt	P56945
neXtProt	NX_P56945
Antibodypedia	BCAR1 antibodies

PROTEIN VIEW

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BCAR1-001		BCAR1-002		BCAR1-003		BCAR1-004		BCAR1-005		BCAR1-006		BCAR1-007		BCAR1-008		BCAR1-009		BCAR1-012		BCAR1-013		BCAR1-015		BCAR1-016		BCAR1-017		BCAR1-019		BCAR1-020		BCAR1-021		BCAR1-201

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
BCAR1-001	ENSP00000377074 ENST00000393422	E9PCV2 Show all » « Hide E9PCV2 [Target identity:100%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 F5H855 [Target identity:94%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 Q8NC57 [Target identity:77%; Query identity:100%] cDNA FLJ90477 fis, clone NT2RP3002738, weakly similar to Homo sapiens enhancer of filamentation (HEF1) mRNA H3BSB2 [Target identity:15%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 H3BSY4 [Target identity:14%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 H3BVF0 [Target identity:13%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 H3BU42 [Target identity:9%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 H3BTB0 [Target identity:6%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 H3BQJ7 [Target identity:5%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1	Show » « Hide SH3-domain containing proteins	Show » « Hide GO:0005925 [focal adhesion] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0008286 [insulin receptor signaling pathway] GO:0016477 [cell migration] GO:0019904 [protein domain specific binding] GO:0030027 [lamellipodium] GO:0030036 [actin cytoskeleton organization] GO:0048008 [platelet-derived growth factor receptor signaling pathway] GO:0048011 [nerve growth factor receptor signaling pathway]	888	95.2	No	0
BCAR1-002	ENSP00000162330 ENST00000162330	P56945 Show all » « Hide P56945 [Direct mapping] Breast cancer anti-estrogen resistance protein 1 F5H855 [Target identity:96%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 Q8NC57 [Target identity:78%; Query identity:100%] cDNA FLJ90477 fis, clone NT2RP3002738, weakly similar to Homo sapiens enhancer of filamentation (HEF1) mRNA H3BSB2 [Target identity:15%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 H3BSY4 [Target identity:14%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 H3BVF0 [Target identity:13%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 H3BU42 [Target identity:9%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 H3BTB0 [Target identity:6%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 H3BQJ7 [Target identity:5%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1	Show » « Hide SH3-domain containing proteins Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level	Show » « Hide GO:0001558 [regulation of cell growth] GO:0001726 [ruffle] GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0007015 [actin filament organization] GO:0007155 [cell adhesion] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007229 [integrin-mediated signaling pathway] GO:0007596 [blood coagulation] GO:0008283 [cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0016477 [cell migration] GO:0017124 [SH3 domain binding] GO:0019901 [protein kinase binding] GO:0019903 [protein phosphatase binding] GO:0019904 [protein domain specific binding] GO:0030027 [lamellipodium] GO:0030036 [actin cytoskeleton organization] GO:0030168 [platelet activation] GO:0030335 [positive regulation of cell migration] GO:0035729 [cellular response to hepatocyte growth factor stimulus] GO:0042981 [regulation of apoptotic process] GO:0048008 [platelet-derived growth factor receptor signaling pathway] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [nerve growth factor receptor signaling pathway] GO:0048012 [hepatocyte growth factor receptor signaling pathway] GO:0050851 [antigen receptor-mediated signaling pathway] GO:0050852 [T cell receptor signaling pathway] GO:0050853 [B cell receptor signaling pathway] GO:0051301 [cell division] GO:0060326 [cell chemotaxis]	870	93.4	No	0
BCAR1-003	ENSP00000392708 ENST00000420641	P56945 Show all » « Hide P56945 [Direct mapping] Breast cancer anti-estrogen resistance protein 1 F5H855 [Target identity:94%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 Q8NC57 [Target identity:77%; Query identity:100%] cDNA FLJ90477 fis, clone NT2RP3002738, weakly similar to Homo sapiens enhancer of filamentation (HEF1) mRNA H3BSB2 [Target identity:15%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 H3BSY4 [Target identity:14%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 H3BVF0 [Target identity:13%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 H3BU42 [Target identity:9%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 H3BTB0 [Target identity:6%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 H3BQJ7 [Target identity:5%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1	Show » « Hide SH3-domain containing proteins Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level	Show » « Hide GO:0001558 [regulation of cell growth] GO:0001726 [ruffle] GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0007015 [actin filament organization] GO:0007155 [cell adhesion] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007229 [integrin-mediated signaling pathway] GO:0007596 [blood coagulation] GO:0008283 [cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0016477 [cell migration] GO:0017124 [SH3 domain binding] GO:0019901 [protein kinase binding] GO:0019903 [protein phosphatase binding] GO:0019904 [protein domain specific binding] GO:0030027 [lamellipodium] GO:0030036 [actin cytoskeleton organization] GO:0030168 [platelet activation] GO:0030335 [positive regulation of cell migration] GO:0035729 [cellular response to hepatocyte growth factor stimulus] GO:0042981 [regulation of apoptotic process] GO:0048008 [platelet-derived growth factor receptor signaling pathway] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [nerve growth factor receptor signaling pathway] GO:0048012 [hepatocyte growth factor receptor signaling pathway] GO:0050851 [antigen receptor-mediated signaling pathway] GO:0050852 [T cell receptor signaling pathway] GO:0050853 [B cell receptor signaling pathway] GO:0051301 [cell division] GO:0060326 [cell chemotaxis]	888	95.5	No	0
BCAR1-004	ENSP00000443841 ENST00000538440	F5H7Z0 Show all » « Hide F5H7Z0 [Target identity:100%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 F5H855 [Target identity:96%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 Q8NC57 [Target identity:78%; Query identity:100%] cDNA FLJ90477 fis, clone NT2RP3002738, weakly similar to Homo sapiens enhancer of filamentation (HEF1) mRNA H3BSB2 [Target identity:15%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 H3BSY4 [Target identity:14%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 H3BVF0 [Target identity:13%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 H3BU42 [Target identity:9%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 H3BTB0 [Target identity:6%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 H3BQJ7 [Target identity:5%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1	Show » « Hide SH3-domain containing proteins	Show » « Hide GO:0005925 [focal adhesion] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0008286 [insulin receptor signaling pathway] GO:0016477 [cell migration] GO:0019904 [protein domain specific binding] GO:0030027 [lamellipodium] GO:0030036 [actin cytoskeleton organization] GO:0048008 [platelet-derived growth factor receptor signaling pathway] GO:0048011 [nerve growth factor receptor signaling pathway]	870	93.3	No	0
BCAR1-005	ENSP00000391669 ENST00000418647	E9PCL5 Show all » « Hide E9PCL5 [Target identity:100%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 F5H855 [Target identity:91%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 Q8NC57 [Target identity:74%; Query identity:100%] cDNA FLJ90477 fis, clone NT2RP3002738, weakly similar to Homo sapiens enhancer of filamentation (HEF1) mRNA H3BSB2 [Target identity:14%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 H3BSY4 [Target identity:13%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 H3BVF0 [Target identity:13%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 H3BU42 [Target identity:8%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 H3BTB0 [Target identity:6%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 H3BQJ7 [Target identity:5%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1	Show » « Hide SH3-domain containing proteins Potentially secreted proteins SignalP predicted secreted proteins	Show » « Hide GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0008286 [insulin receptor signaling pathway] GO:0016477 [cell migration] GO:0019904 [protein domain specific binding] GO:0030027 [lamellipodium] GO:0030036 [actin cytoskeleton organization] GO:0048008 [platelet-derived growth factor receptor signaling pathway] GO:0048011 [nerve growth factor receptor signaling pathway]	916	97.9	No	0
BCAR1-006	ENSP00000440370 ENST00000535626	F5GXV6 Show all » « Hide F5GXV6 [Target identity:100%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1	Show » « Hide SH3-domain containing proteins		722	77.7	No	0
BCAR1-007	ENSP00000455166 ENST00000562556	H3BP62 Show all » « Hide H3BP62 [Target identity:100%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1	Show » « Hide Potentially secreted proteins Secreted proteins predicted by MDSP SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins		57	5.7	Yes	0
BCAR1-008	ENSP00000377072 ENST00000393420	F8WA69 Show all » « Hide F8WA69 [Target identity:100%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 H3BSB2 [Target identity:15%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 H3BSY4 [Target identity:14%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 H3BVF0 [Target identity:13%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 H3BU42 [Target identity:9%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 H3BTB0 [Target identity:6%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 H3BQJ7 [Target identity:5%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1	Show » « Hide SH3-domain containing proteins		888	95.5	No	0
BCAR1-009	ENSP00000440415 ENST00000542031	F5GXA2 Show all » « Hide F5GXA2 [Target identity:100%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 F5H855 [Target identity:96%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 Q8NC57 [Target identity:78%; Query identity:100%] cDNA FLJ90477 fis, clone NT2RP3002738, weakly similar to Homo sapiens enhancer of filamentation (HEF1) mRNA H3BSB2 [Target identity:15%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 H3BSY4 [Target identity:14%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 H3BVF0 [Target identity:13%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 H3BU42 [Target identity:9%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 H3BTB0 [Target identity:6%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 H3BQJ7 [Target identity:5%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1	Show » « Hide SH3-domain containing proteins	Show » « Hide GO:0005925 [focal adhesion] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0008286 [insulin receptor signaling pathway] GO:0016477 [cell migration] GO:0019904 [protein domain specific binding] GO:0030027 [lamellipodium] GO:0030036 [actin cytoskeleton organization] GO:0048008 [platelet-derived growth factor receptor signaling pathway] GO:0048011 [nerve growth factor receptor signaling pathway]	868	93.1	No	0
BCAR1-012	ENSP00000457097 ENST00000563323	H3BTB0 Show all » « Hide H3BTB0 [Target identity:100%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 H3BQJ7 [Target identity:84%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1	Show » « Hide SH3-domain containing proteins		59	6.2	No	0
BCAR1-013	ENSP00000457457 ENST00000561970	H3BU42 Show all » « Hide H3BU42 [Target identity:100%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 H3BTB0 [Target identity:73%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 H3BQJ7 [Target identity:62%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1	Show » « Hide SH3-domain containing proteins		80	8.5	No	0
BCAR1-015	ENSP00000457231 ENST00000567215	H3BQJ7 Show all » « Hide H3BQJ7 [Target identity:100%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1	Show » « Hide SH3-domain containing proteins		50	5.4	No	0
BCAR1-016	ENSP00000456929 ENST00000566465	H3BSY4 Show all » « Hide H3BSY4 [Target identity:100%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 H3BVF0 [Target identity:93%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 H3BU42 [Target identity:62%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 H3BTB0 [Target identity:46%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 H3BQJ7 [Target identity:39%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1	Show » « Hide SH3-domain containing proteins		128	13.8	No	0
BCAR1-017	ENSP00000454702 ENST00000569340				238	25.5	No	0
BCAR1-019	ENSP00000456625 ENST00000568864	H3BSB2 Show all » « Hide H3BSB2 [Target identity:100%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 H3BSY4 [Target identity:94%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 H3BVF0 [Target identity:88%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 H3BU42 [Target identity:59%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 H3BTB0 [Target identity:43%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 H3BQJ7 [Target identity:37%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1	Show » « Hide SH3-domain containing proteins		135	14.4	No	0
BCAR1-020	ENSP00000458088 ENST00000569006	H3BVF0 Show all » « Hide H3BVF0 [Target identity:100%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 H3BU42 [Target identity:66%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 H3BTB0 [Target identity:49%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 H3BQJ7 [Target identity:41%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1	Show » « Hide SH3-domain containing proteins		120	12.8	No	0
BCAR1-021	ENSP00000455810 ENST00000564028	H3BSY4 Show all » « Hide H3BSY4 [Target identity:96%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 H3BVF0 [Target identity:90%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 H3BU42 [Target identity:60%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 H3BTB0 [Target identity:44%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 H3BQJ7 [Target identity:37%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1	Show » « Hide SH3-domain containing proteins		133	14.2	No	0
BCAR1-201	ENSP00000442161 ENST00000546196	F5H855 Show all » « Hide F5H855 [Target identity:100%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 Q8NC57 [Target identity:81%; Query identity:100%] cDNA FLJ90477 fis, clone NT2RP3002738, weakly similar to Homo sapiens enhancer of filamentation (HEF1) mRNA H3BSB2 [Target identity:16%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 H3BSY4 [Target identity:15%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 H3BVF0 [Target identity:14%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 H3BU42 [Target identity:9%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 H3BTB0 [Target identity:7%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1 H3BQJ7 [Target identity:5%; Query identity:100%] Breast cancer anti-estrogen resistance protein 1	Show » « Hide SH3-domain containing proteins	Show » « Hide GO:0005925 [focal adhesion] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0008286 [insulin receptor signaling pathway] GO:0016477 [cell migration] GO:0019904 [protein domain specific binding] GO:0030027 [lamellipodium] GO:0030036 [actin cytoskeleton organization] GO:0048008 [platelet-derived growth factor receptor signaling pathway] GO:0048011 [nerve growth factor receptor signaling pathway]	841	90.1	No	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.