AKR7A2

GENE INFORMATION

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Gene name

AKR7A2 (HGNC Symbol)

Synonyms

AFAR

Description

aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the aldo/keto reductase (AKR) superfamily and AKR7 family, which are involved in the detoxification of aldehydes and ketones. The AKR7 family consists of 3 genes that are present in a cluster on the p arm of chromosome 1. This protein, thought to be localized in the golgi, catalyzes the NADPH-dependent reduction of succinic semialdehyde to the endogenous neuromodulator, gamma-hydroxybutyrate. It may also function as a detoxication enzyme in the reduction of aflatoxin B1 and 2-carboxybenzaldehyde. [provided by RefSeq, Oct 2011]

Chromosome

1 (Chromosome progress)

Cytoband

p36.13

Chromosome location (bp)

19630459 - 19638640

Ensembl

ENSG00000053371 (version 73.37)

Entrez gene

8574

UniProt

O43488 (UniProt - Evidence at protein level)

neXtProt

NX_O43488

Antibodypedia

AKR7A2 antibodies
 

PROTEIN VIEW

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AKR7A2-001
 
AKR7A2-002
 
AKR7A2-006
 
AKR7A2-007
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AKR7A2-001 ENSP00000235835
ENST00000235835
O43488
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Show » Show » 359 39.6 No 0
AKR7A2-002 ENSP00000339084
ENST00000330072
H3BLU7
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314 34.7 No 0
AKR7A2-006 ENSP00000417891
ENST00000481966
H7C4Q7
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55 6.1 No 0
AKR7A2-007 ENSP00000419936
ENST00000489286
205 21.6 No 0