IL17RB

GENERAL INFORMATION

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Gene name

IL17RB

Gene description

Interleukin 17 receptor B

Protein class

Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (kidney)
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in liver and kidney.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.

Data reliability

Supportive based on 1 antibody.
HPA005482
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Adrenal gland

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (kidney)

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

IL17RB (HGNC Symbol)

Synonyms

CRL4, EVI27, IL17BR, IL17RH1

Description

Interleukin 17 receptor B (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a cytokine receptor. This receptor specifically binds to IL17B and IL17E, but does not bind to IL17 and IL17C. This receptor has been shown to mediate the activation of NF-kappaB and the production of IL8 induced by IL17E. The expression of the rat counterpart of this gene was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor. [provided by RefSeq, Jul 2008]

Chromosome

3

Cytoband

p21.1

Chromosome location (bp)

53846580 - 53865800

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000056736 (version 78.38)

Entrez gene

55540

UniProt

Q9NRM6 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NRM6

Antibodypedia

IL17RB antibodies


PROTEIN BROWSER

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ENST00000288167
 
ENST00000494338
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IL17RB-001 ENSP00000288167
ENST00000288167
Q9NRM6
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Show » Show » 502 55.9 Yes 1
IL17RB-004 ENSP00000418638
ENST00000494338
C9IZN0
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Show » 348 38.6 Yes 1