TRAF3IP2

GENE INFORMATION

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Gene name

TRAF3IP2 (HGNC Symbol)

Synonyms

ACT1, C6orf2, C6orf4, C6orf5, C6orf6, CIKS, DKFZP586G0522

Description

TRAF3 interacting protein 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a protein involved in regulating responses to cytokines by members of the Rel/NF-kappaB transcription factor family. These factors play a central role in innate immunity in response to pathogens, inflammatory signals and stress. This gene product interacts with TRAF proteins (tumor necrosis factor receptor-associated factors) and either I-kappaB kinase or MAP kinase to activate either NF-kappaB or Jun kinase. Several alternative transcripts encoding different isoforms have been identified. Another transcript, which does not encode a protein and is transcribed in the opposite orientation, has been identified. Overexpression of this transcript has been shown to reduce expression of at least one of the protein encoding transcripts, suggesting it has a regulatory role in the expression of this gene. [provided by RefSeq, Aug 2009]

Chromosome

6 (Chromosome progress)

Cytoband

q21

Chromosome location (bp)

111877657 - 111927481

Ensembl

ENSG00000056972 (version 73.37)

Entrez gene

10758

UniProt

O43734 (UniProt - Evidence at protein level)

neXtProt

NX_O43734

Antibodypedia

TRAF3IP2 antibodies
 

PROTEIN VIEW

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TRAF3IP2-001
 
TRAF3IP2-002
 
TRAF3IP2-004
 
TRAF3IP2-005
 
TRAF3IP2-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TRAF3IP2-001 ENSP00000345984
ENST00000340026
O43734
Show all »
Show » 574 64.7 No 0
TRAF3IP2-002 ENSP00000357724
ENST00000368735
O43734
Show all »
Show » 109 12.8 No 0
TRAF3IP2-004 ENSP00000357750
ENST00000368761
O43734
Show all »
Show » 565 63.6 No 0
TRAF3IP2-005 ENSP00000352889
ENST00000359831
O43734
Show all »
Show » 564 63.5 No 0
TRAF3IP2-201 ENSP00000376339
ENST00000392556
O43734
Show all »
Show » 153 18.1 No 0