F7

GENE INFORMATION

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Gene name

F7

Synonyms

Description

coagulation factor VII (serum prothrombin conversion accelerator) (HGNC Symbol)

Entrez gene summary

This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in this gene can cause coagulopathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]

Chromosome

13 (Chromosome progress)

Cytoband

q34

Chromosome location (bp)

113760105 - 113774995

Ensembl

ENSG00000057593 (version 73.37)

Entrez gene

2155

UniProt

P08709 (UniProt - Evidence at protein level)

neXtProt

NX_P08709

Antibodypedia

F7 antibodies
 

PROTEIN VIEW

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F7-001
 
F7-002
 
F7-004
 
F7-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

F7-001 ENSP00000364731
ENST00000375581
P08709
Show all »
Show » Show » 466 51.6 Yes 0
F7-002 ENSP00000329546
ENST00000346342
P08709
Show all »
Show » Show » 444 49.3 Yes 0
F7-004 ENSP00000387669
ENST00000444337
E9PH36
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74 7.2 Yes 0
F7-201 ENSP00000442051
ENST00000541084
F5H8B0
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Show » Show » 397 43.6 Yes 0