ATP2B4

GENE INFORMATION

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Gene name

ATP2B4 (HGNC Symbol)

Synonyms

ATP2B2, MXRA1, PMCA4

Description

ATPase, Ca++ transporting, plasma membrane 4 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Chromosome

1 (Chromosome progress)

Cytoband

q32.1

Chromosome location (bp)

203595689 - 203713209

Ensembl

ENSG00000058668 (version 73.37)

Entrez gene

493

UniProt

P23634 (UniProt - Evidence at protein level)

neXtProt

NX_P23634

Antibodypedia

ATP2B4 antibodies
 

PROTEIN VIEW

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ATP2B4-001
 
ATP2B4-002
 
ATP2B4-003
 
ATP2B4-004
 
ATP2B4-006
 
ATP2B4-201
 
ATP2B4-202
 
ATP2B4-203
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ATP2B4-001 ENSP00000350310
ENST00000357681
P23634
Show all »
Show » Show » 1205 133.9 No >9
ATP2B4-002 ENSP00000340930
ENST00000341360
P23634
Show all »
Show » Show » 1170 129.4 No >9
ATP2B4-003 ENSP00000433577
ENST00000484746
Show » 102 11 No 0
ATP2B4-004 ENSP00000391150
ENST00000458092
Show » Show » 117 13.1 No 1
ATP2B4-006 ENSP00000349165
ENST00000356729
Show » 129 14 No 0
ATP2B4-201 ENSP00000356187
ENST00000367218
P23634
Show all »
Show » Show » 1170 129.4 No >9
ATP2B4-202 ENSP00000356188
ENST00000367219
P23634
Show all »
Show » Show » 1158 128.1 No >9
ATP2B4-203 ENSP00000375816
ENST00000391954
P23634
Show all »
Show » Show » 1134 125.3 No 9