CASP8

GENE INFORMATION

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Gene name

CASP8 (HGNC Symbol)

Synonyms

Casp-8, FLICE, MACH, MCH5

Description

caspase 8, apoptosis-related cysteine peptidase (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008]

Chromosome

2 (Chromosome progress)

Cytoband

q33.1

Chromosome location (bp)

202098166 - 202152434

Ensembl

ENSG00000064012 (version 73.37)

Entrez gene

841

UniProt

Q14790 (UniProt - Evidence at protein level)

neXtProt

NX_Q14790

Antibodypedia

CASP8 antibodies
 

PROTEIN VIEW

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 « 
 
CASP8-001
 
CASP8-002
 
CASP8-004
 
CASP8-006
 
CASP8-009
 
CASP8-010
 
CASP8-012
 
CASP8-014
 
CASP8-016
 
CASP8-017
 
CASP8-020
 
CASP8-021
 
CASP8-023
 
CASP8-026
 
CASP8-201
 
CASP8-202
 
CASP8-203
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CASP8-001 ENSP00000407378
ENST00000437283
F8WF39
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58 6.2 No 0
CASP8-002 ENSP00000351273
ENST00000358485
Q14790
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Show » Show » 538 61.8 No 0
CASP8-004 ENSP00000376087
ENST00000392258
Q14790
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Show » Show » 235 27.5 No 0
CASP8-006 ENSP00000264275
ENST00000264275
Q14790
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Show » Show » 496 57.7 No 0
CASP8-009 ENSP00000376091
ENST00000392263
Q14790
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Show » Show » 464 53.8 No 0
CASP8-010 ENSP00000388306
ENST00000447616
E7EQ06
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Show » 209 24.7 No 0
CASP8-012 ENSP00000325722
ENST00000323492
Q14790
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Show » Show » 464 53.8 No 0
CASP8-014 ENSP00000412523
ENST00000432109
Q14790
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Show » Show » 479 55.4 No 0
CASP8-016 ENSP00000390346
ENST00000424461
H7BZM4
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Show » 83 9.4 No 0
CASP8-017 ENSP00000394434
ENST00000444430
H7C0E2
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Show » 258 29.5 No 0
CASP8-020 ENSP00000391709
ENST00000450491
C9JB29
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Show » 149 17.3 No 0
CASP8-021 ENSP00000396869
ENST00000440732
E7EVN1
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Show » 124 14.9 No 0
CASP8-023 ENSP00000397528
ENST00000413726
E7ETB7
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Show » 198 23.5 No 0
CASP8-026 ENSP00000390641
ENST00000429881
E7EQ01
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Show » 116 13.9 No 0
CASP8-201 ENSP00000264274
ENST00000264274
Q14790
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Show » Show » 395 45.9 No 0
CASP8-202 ENSP00000376088
ENST00000392259
Q14790
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Show » Show » 235 27.5 No 0
CASP8-203 ENSP00000376094
ENST00000392266
Q14790
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Show » Show » 220 25.9 No 0