ERBB3

GENE INFORMATION

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Gene name

ERBB3 (HGNC Symbol)

Synonyms

HER3, LCCS2

Description

v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

Chromosome

12 (Chromosome progress)

Cytoband

q13.2

Chromosome location (bp)

56473641 - 56497289

Ensembl

ENSG00000065361 (version 73.37)

Entrez gene

2065

UniProt

P21860 (UniProt - Evidence at protein level)

neXtProt

NX_P21860

Antibodypedia

ERBB3 antibodies
 

PROTEIN VIEW

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 « 
 
ERBB3-001
 
ERBB3-003
 
ERBB3-004
 
ERBB3-005
 
ERBB3-006
 
ERBB3-009
 
ERBB3-010
 
ERBB3-011
 
ERBB3-014
 
ERBB3-020
 
ERBB3-023
 
ERBB3-024
 
ERBB3-201
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ERBB3-001 ENSP00000267101
ENST00000267101
P21860
Show all »
Show » Show » 1342 148.1 Yes 1
ERBB3-003 ENSP00000447510
ENST00000551242
P21860
Show all »
Show » Show » 331 36.5 Yes 0
ERBB3-004 ENSP00000448729
ENST00000549832
B3KWG5
Show all »
Show » Show » 462 50.7 No 0
ERBB3-005 ENSP00000449129
ENST00000553131
F8VW56
Show all »
Show » 583 64.3 No 0
ERBB3-006 ENSP00000415753
ENST00000411731
P21860
Show all »
Show » Show » 183 20.1 Yes 0
ERBB3-009 ENSP00000448946
ENST00000550070
F8VYK4
Show all »
Show » Show » 649 71.6 No 1
ERBB3-010 ENSP00000448636
ENST00000549282
F8VRL0
Show all »
Show » 126 14 Yes 0
ERBB3-011 ENSP00000449138
ENST00000549061
F8VW48
Show all »
Show » 116 13.3 No 0
ERBB3-014 ENSP00000448671
ENST00000550869
F8VRI5
Show all »
43 4.8 No 0
ERBB3-020 ENSP00000449713
ENST00000549672
F8VX90
Show all »
Show » 115 13.2 No 0
ERBB3-023 ENSP00000448483
ENST00000551085
B4DGQ7
Show all »
Show » Show » 921 101.8 Yes 1
ERBB3-024 ENSP00000408340
ENST00000415288
P21860
Show all »
Show » Show » 1283 141.8 No 1
ERBB3-201 ENSP00000399178
ENST00000450146
P21860
Show all »
Show » Show » 699 77.4 No 1