MYLK

GENE INFORMATION

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Gene name

MYLK (HGNC Symbol)

Synonyms

MLCK, MLCK1, MYLK1, smMLCK

Description

myosin light chain kinase (HGNC Symbol)

Entrez gene summary

This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts. [provided by RefSeq, Jul 2008]

Chromosome

3 (Chromosome progress)

Cytoband

q21.1

Chromosome location (bp)

123328896 - 123603178

Ensembl

ENSG00000065534 (version 73.37)

Entrez gene

4638

UniProt

Q15746 (UniProt - Evidence at protein level)

neXtProt

NX_Q15746

Antibodypedia

MYLK antibodies
 

PROTEIN VIEW

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MYLK-001
 
MYLK-002
 
MYLK-003
 
MYLK-004
 
MYLK-009
 
MYLK-010
 
MYLK-018
 
MYLK-019
 
MYLK-201
 
MYLK-202
 
MYLK-203
 
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PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MYLK-001 ENSP00000354004
ENST00000360772
Q15746
Show all »
Show » Show » 1863 205.1 No 0
MYLK-002 ENSP00000417798
ENST00000464489
F8WBL7
Show all »
70 7.5 No 0
MYLK-003 ENSP00000320622
ENST00000346322
Q15746
Show all »
Show » Show » 1845 203.1 No 1
MYLK-004 ENSP00000418335
ENST00000475616
Q15746
Show all »
Show » Show » 1914 210.7 No 1
MYLK-009 ENSP00000422984
ENST00000508240
D6R9C2
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Show » 229 25.3 No 0
MYLK-010 ENSP00000428967
ENST00000418370
Q15746
Show all »
Show » Show » 154 17 No 0
MYLK-018 ENSP00000462118
ENST00000583087
Q15746
Show all »
Show » Show » 154 17 No 0
MYLK-019 ENSP00000463691
ENST00000578202
Q6P2N0
Show all »
Show » 153 16.8 No 0
MYLK-201 ENSP00000346846
ENST00000354792
B4DUE3
Show all »
Show » Show » 714 80.4 No 1
MYLK-202 ENSP00000352088
ENST00000359169
Q15746
Show all »
Show » Show » 1863 205.1 No 0
MYLK-203 ENSP00000353452
ENST00000360304
Q15746
Show all »
Show » Show » 1914 210.7 No 1