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GENE INFORMATION
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The gene information section lists the gene name (HUGO Gene Nomenclature Committee ( HGNC) name if available), any approved gene synonyms, Ensembl gene description, and the Entrez gene summary from the National Center for Biotechnology Information.
The chromosomal and cytoband location of the gene according to Ensembl is reported together with the Ensembl gene identifier and Ensembl database version. The Entrez gene identifier for the gene is also given. If any of the protein products of the gene is linked to a UniProt KB/SWISS-PROT entry, links to the UniProt and the neXtProt databases for these proteins are displayed.
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Gene name |
MYLK (HGNC Symbol) |
Synonyms |
MLCK, MLCK1, MYLK1, smMLCK |
Description |
myosin light chain kinase (HGNC Symbol) |
Entrez gene summary |
This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts. [provided by RefSeq, Jul 2008] |
Chromosome |
3 (Chromosome progress)
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Cytoband |
q21.1 |
Chromosome location (bp) |
123328896 - 123603178 |
Ensembl |
ENSG00000065534 (version 69.37) |
Entrez gene |
4638 |
UniProt |
Q15746 |
neXtProt |
NX_Q15746 |
Antibodypedia |
MYLK antibodies |
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PROTEIN VIEW
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The protein view displays protein features. The tabs at the top of the protein view section can be used to switch between the different splice variants encoded by this gene. The mouse over function displays additional data for the features in the protein view.
At the top of the protein view, the maximum percent sequence identity of the protein to all other proteins from other human genes is shown, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50) ( read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0 and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green.
Common (purple) and unique (grey) regions between alternative processed transcripts from the same gene are also displayed ( read more), and at the bottom of the protein view is the protein scale.
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PROTEIN INFORMATION
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The protein information section displays the alternative protein-coding transcripts (splice variants) encoded by this gene, according to the Ensembl database.
The ENSP identifier links to the Ensembl website for that protein, and the ENST identifier links to the Ensembl website for that transcript. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes to which this protein has been assigned are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column.
The length of the protein (amino acid residues) (according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0 and Phobius and predicted transmembrane region(s) (according to MDM) are also reported.
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Splice variant |
Ensembl |
UniProt |
Protein class |
Gene ontology |
Length (aa) |
Molecular mass (kDa) |
Signal peptide (predicted) |
Transmembrane regions (predicted)
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| MYLK-001 |
ENSP00000354004
ENST00000360772
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Q15746 Show all »
« Hide
Q15746 [Direct mapping]Myosin light chain kinase, smooth muscle Myosin light chain kinase, smooth muscle, deglutamylated form D6R9C2 [Target identity:12%; Query identity:100%]Myosin light chain kinase, smooth muscle, deglutamylated form Q05B97 [Target identity:8%; Query identity:100%]MYLK protein Q05B98 [Target identity:8%; Query identity:100%]MYLK protein Q9UBY6 [Target identity:8%; Query identity:100%]Kinase-related protein; Kinase-related protein isoform 2; Myosin light chain kinase; Myosin, light polypeptide kinase, isoform CRA_e; cDNA, FLJ95241, Homo sapiens myosin, light polypeptide kinase (MYLK), transcriptvariant 8, mRNA Q06S79 [Target identity:4%; Query identity:100%]Long myosin light chain kinase; Myosin light chain kinase, smooth muscle, deglutamylated form
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Kinases CAMK Ser/Thr protein kinases Enzymes Transferases Potential transmembrane proteins SPOCTOPUS predicted membrane proteins Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level
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1863 |
205.1 |
No |
0 |
| MYLK-002 |
ENSP00000417798
ENST00000464489
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F8WBL7 Show all »
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F8WBL7 [Target identity:100%; Query identity:100%]Myosin light chain kinase, smooth muscle, deglutamylated form
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70 |
7.5 |
No |
0 |
| MYLK-003 |
ENSP00000320622
ENST00000346322
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Q15746 Show all »
« Hide
Q15746 [Direct mapping]Myosin light chain kinase, smooth muscle Myosin light chain kinase, smooth muscle, deglutamylated form B4DUE3 [Target identity:38%; Query identity:100%]Myosin light chain kinase, smooth muscle, deglutamylated form; cDNA FLJ53659, highly similar to Myosin light chain kinase, smooth muscle D6R9C2 [Target identity:12%; Query identity:100%]Myosin light chain kinase, smooth muscle, deglutamylated form Q05B98 [Target identity:9%; Query identity:100%]MYLK protein Q05B97 [Target identity:8%; Query identity:100%]MYLK protein Q9UBY6 [Target identity:8%; Query identity:100%]Kinase-related protein; Kinase-related protein isoform 2; Myosin light chain kinase; Myosin, light polypeptide kinase, isoform CRA_e; cDNA, FLJ95241, Homo sapiens myosin, light polypeptide kinase (MYLK), transcriptvariant 8, mRNA Q06S79 [Target identity:4%; Query identity:100%]Long myosin light chain kinase; Myosin light chain kinase, smooth muscle, deglutamylated form
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Kinases CAMK Ser/Thr protein kinases Enzymes Transferases Potential transmembrane proteins Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins 1TM proteins predicted by MDM Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level
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« Hide
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1845 |
203.1 |
No |
1 |
| MYLK-004 |
ENSP00000418335
ENST00000475616
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Q15746 Show all »
« Hide
Q15746 [Direct mapping]Myosin light chain kinase, smooth muscle Myosin light chain kinase, smooth muscle, deglutamylated form B4DUE3 [Target identity:37%; Query identity:100%]Myosin light chain kinase, smooth muscle, deglutamylated form; cDNA FLJ53659, highly similar to Myosin light chain kinase, smooth muscle D6R9C2 [Target identity:11%; Query identity:100%]Myosin light chain kinase, smooth muscle, deglutamylated form Q05B97 [Target identity:8%; Query identity:100%]MYLK protein Q05B98 [Target identity:8%; Query identity:100%]MYLK protein Q9UBY6 [Target identity:8%; Query identity:100%]Kinase-related protein; Kinase-related protein isoform 2; Myosin light chain kinase; Myosin, light polypeptide kinase, isoform CRA_e; cDNA, FLJ95241, Homo sapiens myosin, light polypeptide kinase (MYLK), transcriptvariant 8, mRNA Q06S79 [Target identity:3%; Query identity:100%]Long myosin light chain kinase; Myosin light chain kinase, smooth muscle, deglutamylated form
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Show »
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Kinases CAMK Ser/Thr protein kinases Enzymes Transferases Potential transmembrane proteins Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins 1TM proteins predicted by MDM Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level
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1914 |
210.7 |
No |
1 |
| MYLK-009 |
ENSP00000422984
ENST00000508240
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D6R9C2 Show all »
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D6R9C2 [Target identity:100%; Query identity:100%]Myosin light chain kinase, smooth muscle, deglutamylated form
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229 |
25.3 |
No |
0 |
| MYLK-010 |
ENSP00000428967
ENST00000418370
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Q15746 Show all »
« Hide
Q15746 [Direct mapping]Myosin light chain kinase, smooth muscle Myosin light chain kinase, smooth muscle, deglutamylated form Q9UBY6 [Target identity:100%; Query identity:100%]Kinase-related protein; Kinase-related protein isoform 2; Myosin light chain kinase; Myosin, light polypeptide kinase, isoform CRA_e; cDNA, FLJ95241, Homo sapiens myosin, light polypeptide kinase (MYLK), transcriptvariant 8, mRNA
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Show »
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Kinases CAMK Ser/Thr protein kinases Enzymes Transferases Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level
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Show »
« Hide
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154 |
17 |
No |
0 |
| MYLK-018 |
ENSP00000462118
ENST00000583087
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Q9UBY6 Show all »
« Hide
Q9UBY6 [Target identity:100%; Query identity:100%]Kinase-related protein; Kinase-related protein isoform 2; Myosin light chain kinase; Myosin, light polypeptide kinase, isoform CRA_e; cDNA, FLJ95241, Homo sapiens myosin, light polypeptide kinase (MYLK), transcriptvariant 8, mRNA
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154 |
17 |
No |
0 |
| MYLK-019 |
ENSP00000463691
ENST00000578202
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Q6P2N0 Show all »
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Q6P2N0 [Target identity:100%; Query identity:100%]Myosin light chain kinase; Myosin, light polypeptide kinase, isoform CRA_f; cDNA, FLJ95192, Homo sapiens myosin, light polypeptide kinase (MYLK), transcriptvariant 7, mRNA
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153 |
16.8 |
No |
0 |
| MYLK-201 |
ENSP00000346846
ENST00000354792
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B4DUE3 Show all »
« Hide
B4DUE3 [Target identity:100%; Query identity:100%]Myosin light chain kinase, smooth muscle, deglutamylated form; cDNA FLJ53659, highly similar to Myosin light chain kinase, smooth muscle D6R9C2 [Target identity:32%; Query identity:100%]Myosin light chain kinase, smooth muscle, deglutamylated form Q05B97 [Target identity:23%; Query identity:100%]MYLK protein Q05B98 [Target identity:23%; Query identity:100%]MYLK protein Q9UBY6 [Target identity:21%; Query identity:100%]Kinase-related protein; Kinase-related protein isoform 2; Myosin light chain kinase; Myosin, light polypeptide kinase, isoform CRA_e; cDNA, FLJ95241, Homo sapiens myosin, light polypeptide kinase (MYLK), transcriptvariant 8, mRNA
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Show »
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Potential transmembrane proteins Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins 1TM proteins predicted by MDM
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Show »
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714 |
80.4 |
No |
1 |
| MYLK-202 |
ENSP00000352088
ENST00000359169
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Q15746 Show all »
« Hide
Q15746 [Direct mapping]Myosin light chain kinase, smooth muscle Myosin light chain kinase, smooth muscle, deglutamylated form D6R9C2 [Target identity:12%; Query identity:100%]Myosin light chain kinase, smooth muscle, deglutamylated form Q05B97 [Target identity:8%; Query identity:100%]MYLK protein Q05B98 [Target identity:8%; Query identity:100%]MYLK protein Q9UBY6 [Target identity:8%; Query identity:100%]Kinase-related protein; Kinase-related protein isoform 2; Myosin light chain kinase; Myosin, light polypeptide kinase, isoform CRA_e; cDNA, FLJ95241, Homo sapiens myosin, light polypeptide kinase (MYLK), transcriptvariant 8, mRNA Q06S79 [Target identity:4%; Query identity:100%]Long myosin light chain kinase; Myosin light chain kinase, smooth muscle, deglutamylated form
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Show »
« Hide
Kinases CAMK Ser/Thr protein kinases Enzymes Transferases Potential transmembrane proteins SPOCTOPUS predicted membrane proteins Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level
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Show »
« Hide
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1863 |
205.1 |
No |
0 |
| MYLK-203 |
ENSP00000353452
ENST00000360304
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Q15746 Show all »
« Hide
Q15746 [Direct mapping]Myosin light chain kinase, smooth muscle Myosin light chain kinase, smooth muscle, deglutamylated form B4DUE3 [Target identity:37%; Query identity:100%]Myosin light chain kinase, smooth muscle, deglutamylated form; cDNA FLJ53659, highly similar to Myosin light chain kinase, smooth muscle D6R9C2 [Target identity:11%; Query identity:100%]Myosin light chain kinase, smooth muscle, deglutamylated form Q05B97 [Target identity:8%; Query identity:100%]MYLK protein Q05B98 [Target identity:8%; Query identity:100%]MYLK protein Q9UBY6 [Target identity:8%; Query identity:100%]Kinase-related protein; Kinase-related protein isoform 2; Myosin light chain kinase; Myosin, light polypeptide kinase, isoform CRA_e; cDNA, FLJ95241, Homo sapiens myosin, light polypeptide kinase (MYLK), transcriptvariant 8, mRNA Q06S79 [Target identity:3%; Query identity:100%]Long myosin light chain kinase; Myosin light chain kinase, smooth muscle, deglutamylated form
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Show »
« Hide
Kinases CAMK Ser/Thr protein kinases Enzymes Transferases Potential transmembrane proteins Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins 1TM proteins predicted by MDM Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level
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« Hide
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1914 |
210.7 |
No |
1 |
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