MAP2K4

GENE INFORMATION

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Gene name

MAP2K4 (HGNC Symbol)

Synonyms

JNKK1, MEK4, MKK4, PRKMK4, SERK1

Description

mitogen-activated protein kinase kinase 4 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the mitogen-activated protein kinase (MAPK) family. Members of this family act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. They form a three-tiered signaling module composed of MAPKKKs, MAPKKs, and MAPKs. This protein is phosphorylated at serine and threonine residues by MAPKKKs and subsequently phosphorylates downstream MAPK targets at threonine and tyrosine residues. A similar protein in mouse has been reported to play a role in liver organogenesis. A pseudogene of this gene is located on the long arm of chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Chromosome

17 (Chromosome progress)

Cytoband

p12

Chromosome location (bp)

11924141 - 12047147

Ensembl

ENSG00000065559 (version 73.37)

Entrez gene

6416

UniProt

P45985 (UniProt - Evidence at protein level)

neXtProt

NX_P45985

Antibodypedia

MAP2K4 antibodies
 

PROTEIN VIEW

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 « 
 
MAP2K4-001
 
MAP2K4-002
 
MAP2K4-003
 
MAP2K4-006
 
MAP2K4-008
 
MAP2K4-009
 
MAP2K4-010
 
MAP2K4-011
 
MAP2K4-012
 
MAP2K4-013
 
MAP2K4-014
 
MAP2K4-015
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MAP2K4-001 ENSP00000262445
ENST00000353533
P45985
Show all »
Show » Show » 399 44.3 No 0
MAP2K4-002 ENSP00000410402
ENST00000415385
P45985
Show all »
Show » Show » 410 45.6 No 0
MAP2K4-003 ENSP00000463003
ENST00000581941
J3KTI6
Show all »
Show » Show » 161 18.3 No 0
MAP2K4-006 ENSP00000463854
ENST00000582897
J3QQR2
Show all »
Show » Show » 53 6.2 No 0
MAP2K4-008 ENSP00000467239
ENST00000538465
Show » 16 1.5 No 0
MAP2K4-009 ENSP00000463834
ENST00000579089
J3QQP9
Show all »
Show » Show » 162 18.6 No 0
MAP2K4-010 ENSP00000463507
ENST00000582183
J3QLE2
Show all »
Show » 45 3.9 No 0
MAP2K4-011 ENSP00000473582
ENST00000602811
R4GN68
Show all »
Show » 41 3.6 No 0
MAP2K4-012 ENSP00000473472
ENST00000602375
R4GN37
Show all »
Show » 92 9.6 No 0
MAP2K4-013 ENSP00000473606
ENST00000602305
J3QLE2
Show all »
Show » 45 3.9 No 0
MAP2K4-014 ENSP00000473458
ENST00000602686
R4GN68
Show all »
Show » 41 3.6 No 0
MAP2K4-015 ENSP00000473511
ENST00000602537
R4GN68
Show all »
Show » 41 3.6 No 0