SPI1

GENE INFORMATION

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Gene name

SPI1 (HGNC Symbol)

Synonyms

OF, PU.1, SFPI1, SPI-1, SPI-A

Description

spleen focus forming virus (SFFV) proviral integration oncogene (HGNC Symbol)

Entrez gene summary

This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

11 (Chromosome progress)

Cytoband

p11.2

Chromosome location (bp)

47376411 - 47400127

Ensembl

ENSG00000066336 (version 73.37)

Entrez gene

6688

UniProt

P17947 (UniProt - Evidence at protein level)

neXtProt

NX_P17947

Antibodypedia

SPI1 antibodies
 

PROTEIN VIEW

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SPI1-001
 
SPI1-002
 
SPI1-003
 
SPI1-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SPI1-001 ENSP00000367799
ENST00000378538
P17947
Show all »
Show » Show » 270 31.1 No 0
SPI1-002 ENSP00000438846
ENST00000533968
F5H3K6
Show all »
Show » 245 27.4 No 1
SPI1-003 ENSP00000443865
ENST00000533030
F5GZ94
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35 3.7 No 0
SPI1-004 ENSP00000227163
ENST00000227163
P17947
Show all »
Show » Show » 271 31.2 No 0