FGFR2

GENE INFORMATION

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Gene name

FGFR2 (HGNC Symbol)

Synonyms

BEK, CD332, CEK3, CFD1, ECT1, JWS, K-SAM, KGFR, TK14, TK25

Description

fibroblast growth factor receptor 2 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]

Chromosome

10 (Chromosome progress)

Cytoband

q26.13

Chromosome location (bp)

123237848 - 123357972

Ensembl

ENSG00000066468 (version 73.37)

Entrez gene

2263

UniProt

P21802 (UniProt - Evidence at protein level)

neXtProt

NX_P21802

Antibodypedia

FGFR2 antibodies
 

PROTEIN VIEW

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 « 
 
FGFR2-001
 
FGFR2-003
 
FGFR2-004
 
FGFR2-005
 
FGFR2-006
 
FGFR2-007
 
FGFR2-008
 
FGFR2-009
 
FGFR2-010
 
FGFR2-011
 
FGFR2-012
 
FGFR2-016
 
FGFR2-021
 
FGFR2-024
 
FGFR2-201
 
FGFR2-202
 
FGFR2-203
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FGFR2-001 ENSP00000351276
ENST00000358487
P21802
Show all »
Show » Show » 821 92 Yes 1
FGFR2-003 ENSP00000337665
ENST00000336553
H7BXU9
Show all »
Show » Show » 669 75.2 Yes 1
FGFR2-004 ENSP00000353262
ENST00000360144
P21802
Show all »
Show » Show » 680 76.4 Yes 1
FGFR2-005 ENSP00000358056
ENST00000369060
P21802
Show all »
Show » Show » 705 79.2 Yes 0
FGFR2-006 ENSP00000358052
ENST00000369056
P21802
Show all »
Show » Show » 769 86.2 Yes 1
FGFR2-007 ENSP00000358055
ENST00000369059
E7EVR7
Show all »
Show » Show » 707 79.5 Yes 1
FGFR2-008 ENSP00000474011
ENST00000478859
D3DRD6
Show all »
Show » Show » 593 66.7 No 1
FGFR2-009 ENSP00000263451
ENST00000346997
P21802
Show all »
Show » Show » 819 91.8 Yes 1
FGFR2-010 ENSP00000410294
ENST00000457416
P21802
Show all »
Show » Show » 822 92.1 Yes 1
FGFR2-011 ENSP00000358054
ENST00000369058
P21802
Show all »
Show » Show » 768 86.1 Yes 1
FGFR2-012 ENSP00000348559
ENST00000356226
P21802
Show all »
Show » Show » 704 79.2 Yes 1
FGFR2-016 ENSP00000352309
ENST00000359354
P21802
Show all »
Show » Show » 254 28.3 Yes 0
FGFR2-021 ENSP00000404219
ENST00000429361
H7C265
Show all »
Show » Show » 371 41.9 No 0
FGFR2-024 ENSP00000474109
ENST00000604236
Q9UMB0
Show all »
Show » Show » 251 28 Yes 0
FGFR2-201 ENSP00000309878
ENST00000351936
P21802
Show all »
Show » Show » 785 88.2 Yes 1
FGFR2-202 ENSP00000350166
ENST00000357555
P21802
Show all »
Show » Show » 707 79.3 Yes 1
FGFR2-203 ENSP00000358057
ENST00000369061
P21802
Show all »
Show » Show » 709 79.8 Yes 1