PFKP

GENE INFORMATION

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Gene name

PFKP (HGNC Symbol)

Synonyms

PFK-C, PFKF

Description

phosphofructokinase, platelet (HGNC Symbol)

Entrez gene summary

The PFKP gene encodes the platelet isoform of phosphofructokinase (PFK) (ATP:D-fructose-6-phosphate-1-phosphotransferase, EC 2.7.1.11). PFK catalyzes the irreversible conversion of fructose-6-phosphate to fructose-1,6-bisphosphate and is a key regulatory enzyme in glycolysis. The PFKP gene, which maps to chromosome 10p, is also expressed in fibroblasts. See also the muscle (PFKM; MIM 610681) and liver (PFKL; MIM 171860) isoforms of phosphofructokinase, which map to chromosomes 12q13 and 21q22, respectively. Vora (1981) [PubMed 6451249] determined that full tetrameric phophofructokinase enzyme expressed in platelets can be composed of subunits P4, P3L, and P2L2.[supplied by OMIM, Mar 2008]

Chromosome

10 (Chromosome progress)

Cytoband

p15.2

Chromosome location (bp)

3109712 - 3179904

Ensembl

ENSG00000067057 (version 73.37)

Entrez gene

5214

UniProt

Q01813 (UniProt - Evidence at protein level)

neXtProt

NX_Q01813

Antibodypedia

PFKP antibodies
 

PROTEIN VIEW

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PFKP-001
 
PFKP-002
 
PFKP-003
 
PFKP-004
 
PFKP-005
 
PFKP-007
 
PFKP-009
 
PFKP-011
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PFKP-001 ENSP00000410275
ENST00000433193
Show » 103 11.5 No 0
PFKP-002 ENSP00000385880
ENST00000407806
Q5VSR5
Show all »
Show » Show » 210 22.7 No 0
PFKP-003 ENSP00000370517
ENST00000381125
Q01813
Show all »
Show » Show » 784 85.6 No 0
PFKP-004 ENSP00000370465
ENST00000381075
Q01813
Show all »
Show » Show » 776 85.3 No 0
PFKP-005 ENSP00000410590
ENST00000421751
Q5VSR6
Show all »
Show » 166 17.8 No 0
PFKP-007 ENSP00000370462
ENST00000381072
B1APP8
Show all »
Show » Show » 202 22.9 No 0
PFKP-009 ENSP00000408858
ENST00000415005
B1APP6
Show all »
Show » Show » 240 26.1 Yes 0
PFKP-011 ENSP00000387871
ENST00000413079
Show » Show » 166 17.4 No 0