TNFRSF1A

GENE INFORMATION

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Gene name

TNFRSF1A (HGNC Symbol)

Synonyms

CD120a, TNF-R, TNF-R-I, TNF-R55, TNFAR, TNFR1, TNFR60

Description

Tumor necrosis factor receptor superfamily, member 1A (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease. [provided by RefSeq, Jul 2008]

Chromosome

12

Cytoband

p13.31

Chromosome location (bp)

6328757 - 6342114

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000067182 (version 78.38)

Entrez gene

7132

UniProt

P19438 (UniProt - Evidence at protein level)

neXtProt

NX_P19438

Antibodypedia

TNFRSF1A antibodies
 

PROTEIN VIEW

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TNFRSF1A-001
 
TNFRSF1A-002
 
TNFRSF1A-004
 
TNFRSF1A-010
 
TNFRSF1A-013
 
TNFRSF1A-014
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TNFRSF1A-001 ENSP00000162749
ENST00000162749
P19438
Show all »
Show » Show » 455 50.5 Yes 1
TNFRSF1A-002 ENSP00000438343
ENST00000540022
F5H061
Show all »
Show » Show » 412 45.7 Yes 1
TNFRSF1A-004 ENSP00000380389
ENST00000366159
P19438
Show all »
Show » Show » 218 24.2 Yes 0
TNFRSF1A-010 ENSP00000442919
ENST00000536194
F5H6Z2
Show all »
Show » Show » 118 12.8 Yes 0
TNFRSF1A-013 ENSP00000413224
ENST00000440083
F5H6V7
Show all »
Show » Show » 254 28.1 Yes 0
TNFRSF1A-014 ENSP00000442059
ENST00000539372
F5H8A6
Show all »
Show » Show » 298 33.2 Yes 1