PRKCZ

GENE INFORMATION

? »

Gene name

PRKCZ (HGNC Symbol)

Synonyms

PKC2

Description

protein kinase C, zeta (HGNC Symbol)

Entrez gene summary

Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Chromosome

1 (Chromosome progress)

Cytoband

p36.33

Chromosome location (bp)

1981909 - 2116834

Ensembl

ENSG00000067606 (version 73.37)

Entrez gene

5590

UniProt

Q05513 (UniProt - Evidence at protein level)

neXtProt

NX_Q05513

Antibodypedia

PRKCZ antibodies
 

PROTEIN VIEW

? »
 
 
 « 
 
PRKCZ-001
 
PRKCZ-003
 
PRKCZ-004
 
PRKCZ-006
 
PRKCZ-007
 
PRKCZ-009
 
PRKCZ-010
 
PRKCZ-011
 
PRKCZ-012
 
PRKCZ-015
 
PRKCZ-016
 
PRKCZ-017
 
PRKCZ-018
 
PRKCZ-019
 
PRKCZ-020
 
PRKCZ-021
 
PRKCZ-022
 
PRKCZ-026
 
PRKCZ-201
 
 » 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PRKCZ-001 ENSP00000367830
ENST00000378567
Q05513
Show all »
Show » Show » 592 67.7 No 0
PRKCZ-003 ENSP00000425317
ENST00000482686
D6RDM0
Show all »
Show » 73 8 No 0
PRKCZ-004 ENSP00000422349
ENST00000471018
D6RC84
Show all »
Show » 46 5.1 No 0
PRKCZ-006 ENSP00000427134
ENST00000466352
D6RCN4
Show all »
Show » 25 2.8 No 0
PRKCZ-007 ENSP00000424945
ENST00000468310
F2Z3C5
Show all »
Show » 181 20.7 No 0
PRKCZ-009 ENSP00000383712
ENST00000400921
Q05513
Show all »
Show » Show » 409 46.6 No 0
PRKCZ-010 ENSP00000421219
ENST00000470986
D6RGG1
Show all »
Show » 109 12.2 No 0
PRKCZ-011 ENSP00000422764
ENST00000497183
F2Z2H9
Show all »
Show » 105 11.7 No 0
PRKCZ-012 ENSP00000424398
ENST00000478770
E9PBE1
Show all »
Show » Show » 347 39.5 No 0
PRKCZ-015 ENSP00000426412
ENST00000461106
Q05513
Show all »
Show » Show » 488 56.1 No 0
PRKCZ-016 ENSP00000462105
ENST00000461465
J3KRP7
Show all »
Show » 61 6.7 No 0
PRKCZ-017 ENSP00000424228
ENST00000470596
D6RBD4
Show all »
Show » 98 10.9 No 0
PRKCZ-018 ENSP00000421869
ENST00000496325
D6RAN5
Show all »
Show » 71 7.8 No 0
PRKCZ-019 ENSP00000425643
ENST00000481140
D6RJG4
Show all »
73 8.1 No 0
PRKCZ-020 ENSP00000427085
ENST00000495347
D6RD31
Show all »
Show » 21 2.3 No 0
PRKCZ-021 ENSP00000421350
ENST00000470511
D6RG01
Show all »
Show » 82 9 No 0
PRKCZ-022 ENSP00000424763
ENST00000486681
D6RAU1
Show all »
Show » 136 15.3 No 0
PRKCZ-026 ENSP00000421587
ENST00000503297
D6REZ8
Show all »
Show » 65 7.4 No 0
PRKCZ-201 ENSP00000383711
ENST00000400920
Q05513
Show all »
Show » Show » 409 46.6 No 0