The primary data page shows the detailed antibody staining in 76 different cell types for each analyzed antibody. In addition, for each cell type, a knowledge-based annotated protein expression score based on all analyzed antibodies is displayed furthest to the right. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
The tissues and cell types can be ordered by organ, cell type or alphabetically. If ordered by organ, the tissues are presented in groups according to functional features. If ordered by cell type, the cells are presented in groups related to origin.
This score describes the level of antibody staining observed in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is based on the staining intensity and fraction of stained cells. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
This score describes a knowledge-based best estimate of the protein expression in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is a result of stringent evaluation of immunohistochemical staining pattern, RNA data from internal and external sources and available protein/gene characterization data. More information can be found in Assays & Annotation.
Summarizing texts describe the staining pattern for each antibody based on staining intensity, fraction of stained cells and subcellular localization. More information can be found in Assays & Annotation.
Strong cytoplasmic/membranous immunoreactivity was observed in respiratory epithelia, pancreatic intercalated ducts, gastrointestinal glands, renal tubules, prostate gland and a subset of lymphoid cells. Lung, endocrine cells and cells in the CNS were negative. Most other normal tissues showed weak to moderate staining.
Exocrine pancreas displayed strong cytoplasmic immunoreactivity while strong nuclear and cytoplasmic positivity was observed in gall bladder. Stomach, epididymis, seminal vesicle, neurons, lymphoid tissues and trophoblasts exhibited moderate cytoplasmic with occasional nuclear positivity. Normal tissues in general were weakly stained or negative.
Most of the normal tissues displayed moderate cytoplasmic positivity. Strong staining was observed in a few neuronal cells. Glial cells showed strong cytoplasmic and nuclear staining. Bile ducts, renal glomeruli, smooth muscle, most mesenchymal cells, seminiferous ducts, prostate and spleen were negative.