IDH3G

GENE INFORMATION

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Gene name

IDH3G

Synonyms

Description

isocitrate dehydrogenase 3 (NAD+) gamma (HGNC Symbol)

Entrez gene summary

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the gamma subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. This gene is a candidate gene for periventricular heterotopia. Several alternatively spliced transcript variants of this gene have been described, but only some of their full length natures have been determined. [provided by RefSeq, Jul 2008]

Chromosome

X (Chromosome progress)

Cytoband

q28

Chromosome location (bp)

153051221 - 153059978

Ensembl

ENSG00000067829 (version 73.37)

Entrez gene

3421

UniProt

P51553 (UniProt - Evidence at protein level)

neXtProt

NX_P51553

Antibodypedia

IDH3G antibodies
 

PROTEIN VIEW

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IDH3G-003
 
IDH3G-005
 
IDH3G-006
 
IDH3G-007
 
IDH3G-008
 
IDH3G-009
 
IDH3G-010
 
IDH3G-014
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IDH3G-003 ENSP00000401862
ENST00000444450
E9PF84
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Show » 285 31.4 No 0
IDH3G-005 ENSP00000217901
ENST00000217901
P51553
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Show » Show » 393 42.8 No 0
IDH3G-006 ENSP00000400115
ENST00000454076
O15385
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Show » 211 22.7 No 0
IDH3G-007 ENSP00000408529
ENST00000427365
G5E9Q7
Show all »
Show » 322 35.4 No 0
IDH3G-008 ENSP00000359111
ENST00000370093
E7EQB8
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Show » Show » 340 37.1 No 0
IDH3G-009 ENSP00000401794
ENST00000424541
Show » 155 16.9 No 0
IDH3G-010 ENSP00000402747
ENST00000444338
H7C1W2
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Show » Show » 199 22.4 No 0
IDH3G-014 ENSP00000359110
ENST00000370092
P51553
Show all »
Show » Show » 380 41.5 No 0