ATP2B3

GENE INFORMATION

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Gene name

ATP2B3 (HGNC Symbol)

Synonyms

PMCA3

Description

ATPase, Ca++ transporting, plasma membrane 3 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 3. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Chromosome

X (Chromosome progress)

Cytoband

q28

Chromosome location (bp)

152783134 - 152848397

Ensembl

ENSG00000067842 (version 73.37)

Entrez gene

492

UniProt

Q16720 (UniProt - Evidence at protein level)

neXtProt

NX_Q16720

Antibodypedia

ATP2B3 antibodies
 

PROTEIN VIEW

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ATP2B3-001
 
ATP2B3-002
 
ATP2B3-004
 
ATP2B3-006
 
ATP2B3-201
 
ATP2B3-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ATP2B3-001 ENSP00000359205
ENST00000370186
Q16720
Show all »
Show » Show » 1159 127.1 No >9
ATP2B3-002 ENSP00000343886
ENST00000349466
Q16720
Show all »
Show » Show » 1220 134.2 No >9
ATP2B3-004 ENSP00000377425
ENST00000393842
Q16720
Show all »
Show » Show » 1154 126.6 No >9
ATP2B3-006 ENSP00000352062
ENST00000359149
Q16720
Show all »
Show » Show » 1173 128.5 No >9
ATP2B3-201 ENSP00000263519
ENST00000263519
Q16720
Show all »
Show » Show » 1220 134.2 No >9
ATP2B3-202 ENSP00000359200
ENST00000370181
Q16720
Show all »
Show » Show » 1159 127.1 No >9