ROCK1

GENE INFORMATION

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Gene name

ROCK1 (HGNC Symbol)

Synonyms

p160ROCK

Description

Rho-associated, coiled-coil containing protein kinase 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. [provided by RefSeq, Jul 2008]

Chromosome

18 (Chromosome progress)

Cytoband

q11.1

Chromosome location (bp)

18529701 - 18691812

Ensembl

ENSG00000067900 (version 73.37)

Entrez gene

6093

UniProt

Q13464 (UniProt - Evidence at protein level)

neXtProt

NX_Q13464

Antibodypedia

ROCK1 antibodies
 

PROTEIN VIEW

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ROCK1-001
 
ROCK1-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ROCK1-001 ENSP00000382697
ENST00000399799
Q13464
Show all »
Show » Show » 1354 158.2 No 0
ROCK1-003 ENSP00000462004
ENST00000578051
J3KRH6
Show all »
Show » 99 11.3 No 0