CBFB

GENE INFORMATION

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Gene name

CBFB (HGNC Symbol)

Synonyms

PEBP2B

Description

core-binding factor, beta subunit (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

16 (Chromosome progress)

Cytoband

q22.1

Chromosome location (bp)

67063019 - 67134961

Ensembl

ENSG00000067955 (version 73.37)

Entrez gene

865

UniProt

Q13951 (UniProt - Evidence at protein level)

neXtProt

NX_Q13951

Antibodypedia

CBFB antibodies
 

PROTEIN VIEW

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CBFB-001
 
CBFB-002
 
CBFB-003
 
CBFB-006
 
CBFB-007
 
CBFB-009
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CBFB-001 ENSP00000290858
ENST00000290858
Q13951
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Show » Show » 182 21.5 No 0
CBFB-002 ENSP00000462932
ENST00000565389
Show » Show » 60 6.9 No 0
CBFB-003 ENSP00000415151
ENST00000412916
Q13951
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Show » Show » 187 22 No 0
CBFB-006 ENSP00000456637
ENST00000564034
H3BSC0
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Show » Show » 93 11.1 No 0
CBFB-007 ENSP00000462273
ENST00000561924
J3KS23
Show all »
Show » Show » 82 9.7 No 0
CBFB-009 ENSP00000462148
ENST00000563939
J3KRT0
Show all »
Show » Show » 61 7.3 No 0