PDK3

GENE INFORMATION

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Gene name

PDK3

Synonyms

Description

pyruvate dehydrogenase kinase, isozyme 3 (HGNC Symbol)

Entrez gene summary

The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle, and thus is one of the major enzymes responsible for the regulation of glucose metabolism. The enzymatic activity of PDH is regulated by a phosphorylation/dephosphorylation cycle, and phosphorylation results in inactivation of PDH. The protein encoded by this gene is one of the three pyruvate dehydrogenase kinases that inhibits the PDH complex by phosphorylation of the E1 alpha subunit. This gene is predominantly expressed in the heart and skeletal muscles. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

Chromosome

X (Chromosome progress)

Cytoband

p22.11

Chromosome location (bp)

24483338 - 24557954

Ensembl

ENSG00000067992 (version 73.37)

Entrez gene

5165

UniProt

Q15120 (UniProt - Evidence at protein level)

neXtProt

NX_Q15120

Antibodypedia

PDK3 antibodies
 

PROTEIN VIEW

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PDK3-001
 
PDK3-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PDK3-001 ENSP00000368460
ENST00000379162
Q15120
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Show » Show » 406 46.9 No 0
PDK3-003 ENSP00000387536
ENST00000441463
Q15120
Show all »
Show » Show » 415 48 No 0