ACSL4

GENE INFORMATION

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Gene name

ACSL4 (HGNC Symbol)

Synonyms

ACS4, FACL4, LACS4, MRX63, MRX68

Description

acyl-CoA synthetase long-chain family member 4 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to the mental retardation or Alport syndrome. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]

Chromosome

X (Chromosome progress)

Cytoband

q23

Chromosome location (bp)

108872579 - 108976632

Ensembl

ENSG00000068366 (version 73.37)

Entrez gene

2182

UniProt

O60488 (UniProt - Evidence at protein level)

neXtProt

NX_O60488

Antibodypedia

ACSL4 antibodies
 

PROTEIN VIEW

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ACSL4-001
 
ACSL4-002
 
ACSL4-003
 
ACSL4-006
 
ACSL4-007
 
ACSL4-008
 
ACSL4-009
 
ACSL4-010
 
ACSL4-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ACSL4-001 ENSP00000262835
ENST00000348502
O60488
Show all »
Show » Show » 670 74.4 No 0
ACSL4-002 ENSP00000423077
ENST00000469857
O60488
Show all »
Show » Show » 54 6.2 No 1
ACSL4-003 ENSP00000419171
ENST00000469796
O60488
Show all »
Show » Show » 711 79.2 No 3
ACSL4-006 ENSP00000425378
ENST00000508092
D6RDA8
Show all »
Show » Show » 128 14.6 No 1
ACSL4-007 ENSP00000425408
ENST00000502391
D6RD96
Show all »
Show » Show » 145 16.4 No 1
ACSL4-008 ENSP00000424808
ENST00000505855
D6RF95
Show all »
Show » 154 17.2 No 0
ACSL4-009 ENSP00000421425
ENST00000504980
D6RFW9
Show all »
Show » Show » 126 14.3 No 1
ACSL4-010 ENSP00000423539
ENST00000514500
Show » 156 17 No 0
ACSL4-201 ENSP00000339787
ENST00000340800
O60488
Show all »
Show » Show » 711 79.2 No 3