VPS35

GENERAL INFORMATION

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Gene name

VPS35

Gene description

Vacuolar protein sorting 35 homolog (S. cerevisiae)

Protein class

Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Ubiquitous cytoplasmic expression.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining consistent with RNA expression data.

Data reliability

Supportive based on 1 antibody.
HPA040802
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

VPS35 (HGNC Symbol)

Synonyms

FLJ10752, MEM3, PARK17

Description

Vacuolar protein sorting 35 homolog (S. cerevisiae) (HGNC Symbol)

Entrez gene summary

This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. [provided by RefSeq, Jul 2008]

Chromosome

16

Cytoband

q11.2

Chromosome location (bp)

46656132 - 46689518

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000069329 (version 78.38)

Entrez gene

55737

UniProt

Q96QK1 (UniProt - Evidence at protein level)

neXtProt

NX_Q96QK1

Antibodypedia

VPS35 antibodies


PROTEIN BROWSER

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ENST00000299138
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

VPS35-001 ENSP00000299138
ENST00000299138
Q96QK1
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