CAMK2A

GENE INFORMATION

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Gene name

CAMK2A (HGNC Symbol)

Synonyms

CAMKA, CaMKIINalpha, KIAA0968

Description

calcium/calmodulin-dependent protein kinase II alpha (HGNC Symbol)

Entrez gene summary

The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2008]

Chromosome

5 (Chromosome progress)

Cytoband

q32

Chromosome location (bp)

149599054 - 149669854

Ensembl

ENSG00000070808 (version 73.37)

Entrez gene

815

UniProt

Q9UQM7 (UniProt - Evidence at protein level)

neXtProt

NX_Q9UQM7

Antibodypedia

CAMK2A antibodies
 

PROTEIN VIEW

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CAMK2A-001
 
CAMK2A-002
 
CAMK2A-005
 
CAMK2A-007
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CAMK2A-001 ENSP00000261793
ENST00000348628
Q9UQM7
Show all »
Show » Show » 478 54.1 No 1
CAMK2A-002 ENSP00000381412
ENST00000398376
Q9UQM7
Show all »
Show » Show » 489 55.3 No 1
CAMK2A-005 ENSP00000426607
ENST00000510347
D6RFJ0
Show all »
Show » 91 10.6 No 0
CAMK2A-007 ENSP00000427580
ENST00000515758
D6RHX9
Show all »
Show » 24 2.6 No 0