EPHA8

GENE INFORMATION

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Gene name

EPHA8 (HGNC Symbol)

Synonyms

EEK, Hek3

Description

EPH receptor A8 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. The protein encoded by this gene functions as a receptor for ephrin A2, A3 and A5 and plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system. [provided by RefSeq, Jul 2008]

Chromosome

1 (Chromosome progress)

Cytoband

p36.12

Chromosome location (bp)

22890057 - 22930087

Ensembl

ENSG00000070886 (version 73.37)

Entrez gene

2046

UniProt

P29322 (UniProt - Evidence at protein level)

neXtProt

NX_P29322

Antibodypedia

EPHA8 antibodies
 

PROTEIN VIEW

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EPHA8-001
 
EPHA8-002
 
EPHA8-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

EPHA8-001 ENSP00000166244
ENST00000166244
P29322
Show all »
Show » Show » 1005 111 Yes 2
EPHA8-002 ENSP00000363775
ENST00000374644
P29322
Show all »
Show » Show » 495 53.9 Yes 0
EPHA8-201 ENSP00000440274
ENST00000538803
P29322
Show all »
Show » Show » 495 53.9 Yes 0