ATP2B1

GENE INFORMATION

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Gene name

ATP2B1 (HGNC Symbol)

Synonyms

PMCA1

Description

ATPase, Ca++ transporting, plasma membrane 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 1. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Chromosome

12 (Chromosome progress)

Cytoband

q21.33

Chromosome location (bp)

89981828 - 90103077

Ensembl

ENSG00000070961 (version 73.37)

Entrez gene

490

UniProt

P20020 (UniProt - Evidence at protein level)

neXtProt

NX_P20020

Antibodypedia

ATP2B1 antibodies
 

PROTEIN VIEW

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ATP2B1-001
 
ATP2B1-002
 
ATP2B1-003
 
ATP2B1-004
 
ATP2B1-005
 
ATP2B1-201
 
ATP2B1-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ATP2B1-001 ENSP00000392043
ENST00000428670
P20020
Show all »
Show » Show » 1220 134.7 No >9
ATP2B1-002 ENSP00000352054
ENST00000359142
P20020
Show all »
Show » Show » 1176 129.5 No >9
ATP2B1-003 ENSP00000376869
ENST00000393164
E7ERY9
Show all »
Show » Show » 963 106.9 No 8
ATP2B1-004 ENSP00000447096
ENST00000550716
Show » Show » 162 18.5 No 1
ATP2B1-005 ENSP00000447041
ENST00000551310
F8W1V5
Show all »
Show » Show » 101 11.5 No 1
ATP2B1-201 ENSP00000261173
ENST00000261173
P20020
Show all »
Show » Show » 1220 134.7 No >9
ATP2B1-202 ENSP00000343599
ENST00000348959
P20020
Show all »
Show » Show » 1184 130.6 No 9