TRPM5

GENERAL INFORMATION

? »

Gene name

TRPM5

Gene description

Transient receptor potential cation channel, subfamily M, member 5

Protein class

Predicted membrane proteins
Transporters
Voltage-gated ion channels

Predicted localization

Membrane

Number of transcripts

4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

? »

RNA tissue category

HPA:Group enriched (colon, duodenum, small intestine)
GTEx:Tissue enhanced (colon, small intestine)

Protein evidence

Evidence at protein level

Protein localization

Granular expression in the majority of tissues.

ANTIBODY RELIABILITY

? »

Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 2 antibodies.
HPA042115 , HPA043315
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

? »
RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Prostate



PROTEIN EXPRESSION OVERVIEW

? »

Organ

Expression



RNA EXPRESSION OVERVIEW

? »
HPA dataset
RNA tissue category:  Group enriched (colon, duodenum, small intestine)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (colon, small intestine)

Organ

Expression



GENE INFORMATION

? »

Gene name

TRPM5 (HGNC Symbol)

Synonyms

LTRPC5, MTR1

Description

Transient receptor potential cation channel, subfamily M, member 5 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the transient receptor potential (TRP) protein family, which is a diverse group of proteins with structural features typical of ion channels. This protein plays an important role in taste transduction, and has characteristics of a calcium-activated, non-selective cation channel that carries Na+, K+, and Cs+ ions equally well, but not Ca(2+) ions. It is activated by lower concentrations of intracellular Ca(2+), and inhibited by higher concentrations. It is also a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. This gene is located within the Beckwith-Wiedemann syndrome critical region-1 on chromosome 11p15.5, and has been shown to be imprinted, with exclusive expression from the paternal allele. [provided by RefSeq, Oct 2010]

Chromosome

11

Cytoband

p15.5

Chromosome location (bp)

2404515 - 2423045

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000070985 (version 78.38)

Entrez gene

29850

UniProt

Q9NZQ8 (UniProt - Evidence at transcript level)

neXtProt

NX_Q9NZQ8

Antibodypedia

TRPM5 antibodies


PROTEIN BROWSER

? »
 
 
 
ENST00000155858
 
ENST00000528453
 
ENST00000533060
 
ENST00000533881
 
 
 
 


PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TRPM5-001 ENSP00000155858
ENST00000155858
Q9NZQ8
Show all »
Show » Show » 1165 131.5 No 6
TRPM5-002 ENSP00000434383
ENST00000533881
Q9NZQ8
Show all »
Show » Show » 1159 130.8 No 6
TRPM5-003 ENSP00000434121
ENST00000533060
E9PRW0
Show all »
Show » Show » 1173 132.3 No 6
TRPM5-004 ENSP00000436809
ENST00000528453
E9PQF7
Show all »
Show » Show » 1166 131.5 No 6