TRPM5

GENE INFORMATION

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Gene name

TRPM5 (HGNC Symbol)

Synonyms

LTRPC5, MTR1

Description

transient receptor potential cation channel, subfamily M, member 5 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the transient receptor potential (TRP) protein family, which is a diverse group of proteins with structural features typical of ion channels. This protein plays an important role in taste transduction, and has characteristics of a calcium-activated, non-selective cation channel that carries Na+, K+, and Cs+ ions equally well, but not Ca(2+) ions. It is activated by lower concentrations of intracellular Ca(2+), and inhibited by higher concentrations. It is also a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. This gene is located within the Beckwith-Wiedemann syndrome critical region-1 on chromosome 11p15.5, and has been shown to be imprinted, with exclusive expression from the paternal allele. [provided by RefSeq, Oct 2010]

Chromosome

11 (Chromosome progress)

Cytoband

p15.5

Chromosome location (bp)

2425745 - 2444275

Ensembl

ENSG00000070985 (version 73.37)

Entrez gene

29850

UniProt

Q9NZQ8 (UniProt - Evidence at transcript level)

neXtProt

NX_Q9NZQ8

Antibodypedia

TRPM5 antibodies
 

PROTEIN VIEW

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TRPM5-001
 
TRPM5-002
 
TRPM5-003
 
TRPM5-004
 
TRPM5-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TRPM5-001 ENSP00000155858
ENST00000155858
Q9NZQ8
Show all »
Show » Show » 1165 131.5 No 6
TRPM5-002 ENSP00000434383
ENST00000533881
Q9NZQ8
Show all »
Show » Show » 1159 130.8 No 6
TRPM5-003 ENSP00000434121
ENST00000533060
E9PRW0
Show all »
Show » 1173 132.3 No 6
TRPM5-004 ENSP00000436809
ENST00000528453
E9PQF7
Show all »
Show » 1166 131.5 No 6
TRPM5-201 ENSP00000387965
ENST00000452833
Q9NZQ8
Show all »
Show » Show » 1167 131.7 No 6