MAP4K4

GENE INFORMATION

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Gene name

MAP4K4 (HGNC Symbol)

Synonyms

FLH21957, HGK, NIK

Description

mitogen-activated protein kinase kinase kinase kinase 4 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Chromosome

2 (Chromosome progress)

Cytoband

q11.2

Chromosome location (bp)

102313312 - 102511149

Ensembl

ENSG00000071054 (version 73.37)

Entrez gene

9448

UniProt

O95819 (UniProt - Evidence at protein level)

neXtProt

NX_O95819

Antibodypedia

MAP4K4 antibodies
 

PROTEIN VIEW

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 « 
 
MAP4K4-001
 
MAP4K4-002
 
MAP4K4-003
 
MAP4K4-004
 
MAP4K4-005
 
MAP4K4-006
 
MAP4K4-008
 
MAP4K4-011
 
MAP4K4-201
 
MAP4K4-202
 
MAP4K4-203
 
MAP4K4-204
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MAP4K4-001 ENSP00000314363
ENST00000347699
O95819
Show all »
Show » Show » 1239 142.1 No 0
MAP4K4-002 ENSP00000392830
ENST00000425019
E7EN19
Show all »
Show » Show » 1272 144.9 No 0
MAP4K4-003 ENSP00000389752
ENST00000413150
E7ENQ1
Show all »
Show » Show » 1154 132.2 No 0
MAP4K4-004 ENSP00000409720
ENST00000417294
H7C360
Show all »
Show » Show » 1170 134.2 No 0
MAP4K4-005 ENSP00000387370
ENST00000456652
E7EX83
Show all »
Show » Show » 1038 119 No 0
MAP4K4-006 ENSP00000396066
ENST00000421882
Show » Show » 1056 121.3 No 0
MAP4K4-008 ENSP00000403016
ENST00000427603
E7ETN6
Show all »
Show » 102 11.4 No 0
MAP4K4-011 ENSP00000414766
ENST00000418101
H7C3Z6
Show all »
258 31.1 No 0
MAP4K4-201 ENSP00000303600
ENST00000302217
C9J840
Show all »
Show » Show » 1042 119.5 No 0
MAP4K4-202 ENSP00000313644
ENST00000324219
G5E948
Show all »
Show » Show » 1320 151.1 No 0
MAP4K4-203 ENSP00000281111
ENST00000350198
G3XAA2
Show all »
Show » Show » 1166 133.6 No 0
MAP4K4-204 ENSP00000343658
ENST00000350878
E7ESS2
Show all »
Show » Show » 1279 146 Yes 0