TCF3

GENE INFORMATION

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Gene name

TCF3 (HGNC Symbol)

Synonyms

bHLHb21, E2A, E47, ITF1, MGC129647, MGC129648, VDIR

Description

transcription factor 3 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1;19), with PBX1), childhood leukemia (t(19;19), with TFPT) and acute leukemia (t(12;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Sep 2011]

Chromosome

19 (Chromosome progress)

Cytoband

p13.3

Chromosome location (bp)

1609291 - 1652604

Ensembl

ENSG00000071564 (version 73.37)

Entrez gene

6929

UniProt

P15923 (UniProt - Evidence at protein level)

neXtProt

NX_P15923

Antibodypedia

TCF3 antibodies
 

PROTEIN VIEW

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TCF3-001
 
TCF3-002
 
TCF3-003
 
TCF3-004
 
TCF3-005
 
TCF3-006
 
TCF3-007
 
TCF3-008
 
TCF3-010
 
TCF3-011
 
TCF3-012
 
TCF3-013
 
TCF3-014
 
TCF3-016
 
TCF3-018
 
TCF3-019
 
TCF3-201
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TCF3-001 ENSP00000262965
ENST00000262965
P15923
Show all »
Show » Show » 654 67.6 No 0
TCF3-002 ENSP00000468487
ENST00000588136
P15923
Show all »
Show » Show » 651 67.3 No 0
TCF3-003 ENSP00000378813
ENST00000395423
Q2TB39
Show all »
Show » Show » 658 68.5 No 0
TCF3-004 ENSP00000465510
ENST00000585731
P15923
Show all »
Show » Show » 141 16.1 No 0
TCF3-005 ENSP00000396363
ENST00000453954
K7EMM4
Show all »
Show » Show » 566 58.7 No 0
TCF3-006 ENSP00000466952
ENST00000590436
Show » 113 11.3 No 0
TCF3-007 ENSP00000466954
ENST00000586318
K7ENI0
Show all »
Show » Show » 95 10 No 0
TCF3-008 ENSP00000466052
ENST00000587235
K7ELF3
Show all »
Show » Show » 213 21.8 No 0
TCF3-010 ENSP00000467388
ENST00000586410
Show » 94 9.3 No 0
TCF3-011 ENSP00000467972
ENST00000586164
K7EJN4
Show all »
Show » 51 5.5 No 0
TCF3-012 ENSP00000465251
ENST00000592395
K7EJN4
Show all »
Show » 51 5.5 No 0
TCF3-013 ENSP00000467508
ENST00000587425
K7EPS2
Show all »
Show » Show » 163 18.5 No 0
TCF3-014 ENSP00000468481
ENST00000593064
K7EKB9
Show all »
Show » Show » 204 22.5 No 0
TCF3-016 ENSP00000465549
ENST00000592628
K7EKB9
Show all »
Show » Show » 179 20.1 No 0
TCF3-018 ENSP00000465481
ENST00000585855
K7EK65
Show all »
Show » 82 8.7 No 0
TCF3-019 ENSP00000466565
ENST00000590684
K7EMM4
Show all »
Show » Show » 159 18.1 No 0
TCF3-201 ENSP00000344375
ENST00000344749
P15923
Show all »
Show » Show » 651 67.3 No 0