PRKACA

GENE INFORMATION

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Gene name

PRKACA (HGNC Symbol)

Synonyms

PKACa

Description

protein kinase, cAMP-dependent, catalytic, alpha (HGNC Symbol)

Entrez gene summary

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Chromosome

19 (Chromosome progress)

Cytoband

p13.12

Chromosome location (bp)

14202500 - 14228896

Ensembl

ENSG00000072062 (version 73.37)

Entrez gene

5566

UniProt

P17612 (UniProt - Evidence at protein level)

neXtProt

NX_P17612

Antibodypedia

PRKACA antibodies
 

PROTEIN VIEW

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PRKACA-001
 
PRKACA-002
 
PRKACA-003
 
PRKACA-006
 
PRKACA-008
 
PRKACA-010
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PRKACA-001 ENSP00000309591
ENST00000308677
P17612
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Show » Show » 351 40.6 No 0
PRKACA-002 ENSP00000466976
ENST00000590853
K7ENJ5
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124 13.6 No 0
PRKACA-003 ENSP00000466651
ENST00000589994
P17612
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Show » Show » 343 39.8 No 0
PRKACA-006 ENSP00000466289
ENST00000593092
Q15136
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Show » 207 24 No 0
PRKACA-008 ENSP00000466660
ENST00000589284
K7EMV1
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Show » 25 3 No 0
PRKACA-010 ENSP00000468352
ENST00000587372
K7EMV1
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Show » Show » 251 28.9 No 0