LPHN1

GENE INFORMATION

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Gene name

LPHN1 (HGNC Symbol)

Synonyms

CIRL1, KIAA0821, LEC2

Description

latrophilin 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]

Chromosome

19 (Chromosome progress)

Cytoband

p13.12

Chromosome location (bp)

14260750 - 14316999

Ensembl

ENSG00000072071 (version 73.37)

Entrez gene

22859

UniProt

O94910 (UniProt - Evidence at protein level)

neXtProt

NX_O94910

Antibodypedia

LPHN1 antibodies
 

PROTEIN VIEW

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LPHN1-001
 
LPHN1-002
 
LPHN1-004
 
LPHN1-005
 
LPHN1-006
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

LPHN1-001 ENSP00000340688
ENST00000340736
O94910
Show all »
Show » Show » 1474 162.7 Yes 7
LPHN1-002 ENSP00000355328
ENST00000361434
O94910
Show all »
Show » Show » 1469 162.1 Yes 7
LPHN1-004 ENSP00000468711
ENST00000589616
K7ESH3
Show all »
225 24.7 No 0
LPHN1-005 ENSP00000465453
ENST00000592164
Show » Show » 264 28.1 No 0
LPHN1-006 ENSP00000468197
ENST00000593005
Show » 243 25.7 No 0