ACTN1

GENE INFORMATION

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Gene name

ACTN1

Synonyms

Description

actinin, alpha 1 (HGNC Symbol)

Entrez gene summary

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

14 (Chromosome progress)

Cytoband

q24.1

Chromosome location (bp)

69340860 - 69446157

Ensembl

ENSG00000072110 (version 73.37)

Entrez gene

87

UniProt

P12814 (UniProt - Evidence at protein level)

neXtProt

NX_P12814

Antibodypedia

ACTN1 antibodies
 

PROTEIN VIEW

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 « 
 
ACTN1-001
 
ACTN1-002
 
ACTN1-005
 
ACTN1-006
 
ACTN1-007
 
ACTN1-011
 
ACTN1-012
 
ACTN1-013
 
ACTN1-014
 
ACTN1-015
 
ACTN1-016
 
ACTN1-019
 
ACTN1-020
 
ACTN1-022
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ACTN1-001 ENSP00000193403
ENST00000193403
P12814
Show all »
Show » Show » 892 103.1 No 0
ACTN1-002 ENSP00000414272
ENST00000438964
P12814
Show all »
Show » Show » 887 102.7 No 0
ACTN1-005 ENSP00000377941
ENST00000394419
P12814
Show all »
Show » Show » 914 105.6 No 0
ACTN1-006 ENSP00000439828
ENST00000538545
B7TY16
Show all »
Show » Show » 930 107.1 No 0
ACTN1-007 ENSP00000366035
ENST00000376839
H9KV75
Show all »
Show » Show » 822 94.8 No 0
ACTN1-011 ENSP00000450764
ENST00000556433
G3V2N5
Show all »
Show » Show » 261 29.6 No 0
ACTN1-012 ENSP00000450903
ENST00000555616
G3V2W4
Show all »
Show » Show » 238 27.1 No 0
ACTN1-013 ENSP00000451086
ENST00000553659
G3V380
Show all »
Show » 72 8.2 No 0
ACTN1-014 ENSP00000452423
ENST00000556571
G3V5M4
Show all »
Show » Show » 126 14 No 0
ACTN1-015 ENSP00000450925
ENST00000553370
G3V2X9
Show all »
Show » Show » 144 16.3 No 0
ACTN1-016 ENSP00000450618
ENST00000553779
G3V2E8
Show all »
Show » Show » 85 9.4 No 0
ACTN1-019 ENSP00000444422
ENST00000544964
H7C5W8
Show all »
Show » 297 34.3 No 0
ACTN1-020 ENSP00000450625
ENST00000553290
Q5ZEZ4
Show all »
Show » 207 24.3 No 0
ACTN1-022 ENSP00000452254
ENST00000555075
Show » 251 28.8 No 0