SREBF1

GENE INFORMATION

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Gene name

SREBF1 (HGNC Symbol)

Synonyms

bHLHd1, SREBP-1c, SREBP1

Description

sterol regulatory element binding transcription factor 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

17 (Chromosome progress)

Cytoband

p11.2

Chromosome location (bp)

17713713 - 17740325

Ensembl

ENSG00000072310 (version 73.37)

Entrez gene

6720

UniProt

P36956 (UniProt - Evidence at protein level)

neXtProt

NX_P36956

Antibodypedia

SREBF1 antibodies
 

PROTEIN VIEW

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SREBF1-002
 
SREBF1-003
 
SREBF1-004
 
SREBF1-005
 
SREBF1-014
 
SREBF1-015
 
SREBF1-016
 
SREBF1-017
 
SREBF1-018
 
SREBF1-021
 
SREBF1-026
 
SREBF1-201
 
SREBF1-202
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SREBF1-002 ENSP00000261646
ENST00000261646
P36956
Show all »
Show » Show » 1147 121.7 No 2
SREBF1-003 ENSP00000348069
ENST00000355815
P36956
Show all »
Show » Show » 1177 124.6 No 2
SREBF1-004 ENSP00000379106
ENST00000395757
B5MD58
Show all »
Show » Show » 893 95.9 No 2
SREBF1-005 ENSP00000474121
ENST00000395756
113 11.5 No 0
SREBF1-014 ENSP00000466453
ENST00000486311
K7EMD1
Show all »
157 17.1 No 0
SREBF1-015 ENSP00000464923
ENST00000478616
K7EIW8
Show all »
163 17.1 No 0
SREBF1-016 ENSP00000466643
ENST00000485080
K7EMT8
Show all »
110 12 Yes 0
SREBF1-017 ENSP00000463474
ENST00000577897
J3QLB6
Show all »
Show » Show » 66 6.4 No 0
SREBF1-018 ENSP00000379100
ENST00000395751
J3QLB6
Show all »
Show » Show » 216 22.5 No 0
SREBF1-021 ENSP00000411516
ENST00000423161
F6V242
Show all »
Show » Show » 325 33.2 No 0
SREBF1-026 ENSP00000465747
ENST00000578469
31 3.1 No 0
SREBF1-201 ENSP00000345822
ENST00000338854
P36956
Show all »
Show » Show » 1071 113.6 No 2
SREBF1-202 ENSP00000413389
ENST00000435530
B0I4X3
Show all »
Show » Show » 470 48.3 No 0