UBE2D1

GENE INFORMATION

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Gene name

UBE2D1 (HGNC Symbol)

Synonyms

E2(17)KB1, SFT, UBC4/5, UBCH5, UbcH5A

Description

ubiquitin-conjugating enzyme E2D 1 (HGNC Symbol)

Entrez gene summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

Chromosome

10 (Chromosome progress)

Cytoband

q21.1

Chromosome location (bp)

60094735 - 60130513

Ensembl

ENSG00000072401 (version 73.37)

Entrez gene

7321

UniProt

P51668 (UniProt - Evidence at protein level)

neXtProt

NX_P51668

Antibodypedia

UBE2D1 antibodies
 

PROTEIN VIEW

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UBE2D1-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

UBE2D1-001 ENSP00000363019
ENST00000373910
P51668
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