CLCN4

GENE INFORMATION

? »

Gene name

CLCN4 (HGNC Symbol)

Synonyms

ClC-4, CLC4

Description

chloride channel, voltage-sensitive 4 (HGNC Symbol)

Entrez gene summary

The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 4 has an evolutionary conserved CpG island and is conserved in both mouse and hamster. This gene is mapped in close proximity to APXL (Apical protein Xenopus laevis-like) and OA1 (Ocular albinism type I), which are both located on the human X chromosome at band p22.3. The physiological role of chloride channel 4 remains unknown but may contribute to the pathogenesis of neuronal disorders. Alternate splicing results in two transcript variants that encode different proteins. [provided by RefSeq, Mar 2012]

Chromosome

X (Chromosome progress)

Cytoband

p22.2

Chromosome location (bp)

10125024 - 10205700

Ensembl

ENSG00000073464 (version 73.37)

Entrez gene

1183

UniProt

P51793 (UniProt - Evidence at protein level)

neXtProt

NX_P51793

Antibodypedia

CLCN4 antibodies
 

PROTEIN VIEW

? »
 
 
 
CLCN4-001
 
CLCN4-002
 
CLCN4-003
 
CLCN4-201
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CLCN4-001 ENSP00000370213
ENST00000380833
P51793
Show all »
Show » Show » 760 84.9 No >9
CLCN4-002 ENSP00000403064
ENST00000454850
E9PFB5
Show all »
Show » Show » 152 17.2 No 1
CLCN4-003 ENSP00000370209
ENST00000380829
G3XAG5
Show all »
Show » Show » 729 81.3 No >9
CLCN4-201 ENSP00000405754
ENST00000421085
B7Z5Z4
Show all »
Show » Show » 666 74.3 No >9