SDHA

GENERAL INFORMATION

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Gene name

SDHA

Gene description

Succinate dehydrogenase complex, subunit A, flavoprotein (Fp)

Protein class

Citric acid cycle related proteins
Disease related genes
Enzymes
Mitochondrial proteins
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

6
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Ubiquitous cytoplasmic expression with a granular pattern.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 2 antibodies.
HPA041981 , CAB034929
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Heart muscle

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

SDHA (HGNC Symbol)

Synonyms

FP, SDH2, SDHF

Description

Succinate dehydrogenase complex, subunit A, flavoprotein (Fp) (HGNC Symbol)

Entrez gene summary

This gene encodes a major catalytic subunit of succinate-ubiquinone oxidoreductase, a complex of the mitochondrial respiratory chain. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. Mutations in this gene have been associated with a form of mitochondrial respiratory chain deficiency known as Leigh Syndrome. A pseudogene has been identified on chromosome 3q29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]

Chromosome

5

Cytoband

p15.33

Chromosome location (bp)

218241 - 256700

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000073578 (version 78.38)

Entrez gene

6389

UniProt

P31040 (UniProt - Evidence at protein level)

neXtProt

NX_P31040

Antibodypedia

SDHA antibodies


PROTEIN BROWSER

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ENST00000264932
 
ENST00000504309
 
ENST00000509564
 
ENST00000510361
 
ENST00000515815
 
ENST00000617470
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SDHA-001 ENSP00000264932
ENST00000264932
P31040
Show all »
Show » Show » 664 72.7 No 0
SDHA-002 ENSP00000426514
ENST00000504309
D6RFM5
Show all »
Show » Show » 583 63.6 No 0
SDHA-004 ENSP00000427703
ENST00000510361
P31040
Show all »
Show » Show » 616 67.3 No 0
SDHA-017 ENSP00000422404
ENST00000515815
Show » 126 13.5 No 0
SDHA-018 ENSP00000421911
ENST00000509564
H0Y8S2
Show all »
Show » Show » 101 11.1 No 0
SDHA-201 ENSP00000484230
ENST00000617470
Show » Show » 519 56.7 No 0