GLI2

GENE INFORMATION

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Gene name

GLI2 (HGNC Symbol)

Synonyms

HPE9, THP1, THP2

Description

GLI family zinc finger 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a protein which belongs to the C2H2-type zinc finger protein subclass of the Gli family. Members of this subclass are characterized as transcription factors which bind DNA through zinc finger motifs. These motifs contain conserved H-C links. Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in the embryonal carcinoma cell. The protein encoded by this gene localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. The encoded protein is associated with several phenotypes- Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

q14.2

Chromosome location (bp)

121493199 - 121750229

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000074047 (version 75.37)

Entrez gene

2736

UniProt

P10070 (UniProt - Evidence at protein level)

neXtProt

NX_P10070

Antibodypedia

GLI2 antibodies
 

PROTEIN VIEW

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 « 
 
GLI2-001
 
GLI2-002
 
GLI2-004
 
GLI2-005
 
GLI2-006
 
GLI2-007
 
GLI2-009
 
GLI2-011
 
GLI2-012
 
GLI2-201
 
GLI2-202
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GLI2-001 ENSP00000400593
ENST00000438299
F2Z2B4
Show all »
Show » 67 6.6 No 0
GLI2-002 ENSP00000403715
ENST00000452692
F2Z2B4
Show all »
Show » 67 6.6 No 0
GLI2-004 ENSP00000415773
ENST00000437950
F2Z2B4
Show all »
Show » 67 6.6 No 0
GLI2-005 ENSP00000397488
ENST00000445186
F2Z2B4
Show all »
Show » 67 6.6 No 0
GLI2-006 ENSP00000344473
ENST00000341310
F2Z2B4
Show all »
Show » 67 6.6 No 0
GLI2-007 ENSP00000398992
ENST00000418323
Q1PSW9
Show all »
Show » Show » 82 8.5 No 0
GLI2-009 ENSP00000390436
ENST00000452319
P10070
Show all »
Show » Show » 1586 167.8 No 0
GLI2-011 ENSP00000402383
ENST00000433812
H7C1U2
Show all »
Show » 56 5.2 No 0
GLI2-012 ENSP00000441454
ENST00000360874
H0YG23
Show all »
Show » 176 18.4 No 0
GLI2-201 ENSP00000312694
ENST00000314490
P10070
Show all »
Show » Show » 829 88.1 No 0
GLI2-202 ENSP00000354586
ENST00000361492
P10070
Show all »
Show » Show » 1586 167.8 No 0