CA12

GENERAL INFORMATION

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Gene name

CA12

Gene description

Carbonic anhydrase XII

Protein class

Disease related genes
Enzymes
Potential drug targets
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (kidney)
GTEx:Tissue enhanced (kidney)

Protein evidence

Evidence at protein level

Protein localization

Membranous expression in several cell types, most abundant in intestinal tract and renal tubules.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining consistent with RNA expression data.

Data reliability

Supportive based on 4 antibodies.
HPA008773 , CAB025181 , CAB062549 , CAB068179
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (kidney)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (kidney)

Organ

Expression



GENE INFORMATION

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Gene name

CA12 (HGNC Symbol)

Synonyms

HsT18816

Description

Carbonic anhydrase XII (HGNC Symbol)

Entrez gene summary

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. This gene product is a type I membrane protein that is highly expressed in normal tissues, such as kidney, colon and pancreas, and has been found to be overexpressed in 10% of clear cell renal carcinomas. Three transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2014]

Chromosome

15

Cytoband

q22.2

Chromosome location (bp)

63321378 - 63382161

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000074410 (version 78.38)

Entrez gene

771

UniProt

O43570 (UniProt - Evidence at protein level)

neXtProt

NX_O43570

Antibodypedia

CA12 antibodies


PROTEIN BROWSER

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ENST00000178638
 
ENST00000344366
 
ENST00000422263
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CA12-001 ENSP00000178638
ENST00000178638
O43570
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Show » Show » 354 39.5 Yes 1
CA12-002 ENSP00000343088
ENST00000344366
O43570
Show all »
Show » Show » 343 38.4 Yes 1
CA12-003 ENSP00000403028
ENST00000422263
B3KUB4
Show all »
Show » Show » 283 31.9 Yes 1