SLC24A1

GENERAL INFORMATION

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Gene name

SLC24A1

Gene description

Solute carrier family 24 (sodium/potassium/calcium exchanger), member 1

Protein class

Disease related genes
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

Intracellular,Membrane

Number of transcripts

7
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Mixed

Protein evidence

Evidence at protein level

Protein localization

External data suggests expression in retina. RNA-based expert annotation gave inconclusive results.

ANTIBODY RELIABILITY

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Data reliability
description

No internal RNA expression data available for correlation. Pending additional tissues.

Data reliability

Uncertain based on 1 antibody.
HPA039370
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.


RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Mixed

Organ

Expression



GENE INFORMATION

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Gene name

SLC24A1 (HGNC Symbol)

Synonyms

CSNB1D, HsT17412, KIAA0702, NCKX, NCKX1, RODX

Description

Solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the potassium-dependent sodium/calcium exchanger protein family. The encoded protein plays an important role in sodium/calcium exchange in retinal rod and cone photoreceptors by mediating the extrusion of one calcium ion and one potassium ion in exchange for four sodium ions. Mutations in this gene may play a role in congenital stationary night blindness. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

Chromosome

15

Cytoband

q22.31

Chromosome location (bp)

65611366 - 65660995

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000074621 (version 78.38)

Entrez gene

9187

UniProt

O60721 (UniProt - Evidence at protein level)

neXtProt

NX_O60721

Antibodypedia

SLC24A1 antibodies


PROTEIN BROWSER

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ENST00000261892
 
ENST00000339868
 
ENST00000399033
 
ENST00000505666
 
ENST00000537259
 
ENST00000544319
 
ENST00000546330
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SLC24A1-001 ENSP00000261892
ENST00000261892
O60721
Show all »
Show » Show » 1099 121.4 No 8
SLC24A1-002 ENSP00000439693
ENST00000537259
F5H127
Show all »
Show » Show » 1012 111.6 No 6
SLC24A1-004 ENSP00000381991
ENST00000399033
O60721
Show all »
Show » Show » 1069 117.6 No 9
SLC24A1-005 ENSP00000439190
ENST00000546330
O60721
Show all »
Show » Show » 1081 119.5 No 8
SLC24A1-007 ENSP00000445163
ENST00000544319
F5H483
Show all »
Show » Show » 985 109.1 No 9
SLC24A1-011 ENSP00000445577
ENST00000505666
Show » 56 5.7 No 0
SLC24A1-201 ENSP00000341837
ENST00000339868
O60721
Show all »
Show » Show » 1069 117.6 No >9