ACACB

GENE INFORMATION

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Gene name

ACACB (HGNC Symbol)

Synonyms

ACC2, ACCB, HACC275

Description

acetyl-CoA carboxylase beta (HGNC Symbol)

Entrez gene summary

Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. ACC-beta is thought to control fatty acid oxidation by means of the ability of malonyl-CoA to inhibit carnitine-palmitoyl-CoA transferase I, the rate-limiting step in fatty acid uptake and oxidation by mitochondria. ACC-beta may be involved in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. There is evidence for the presence of two ACC-beta isoforms. [provided by RefSeq, Jul 2008]

Chromosome

12 (Chromosome progress)

Cytoband

q24.11

Chromosome location (bp)

109554400 - 109706031

Ensembl

ENSG00000076555 (version 73.37)

Entrez gene

32

UniProt

O00763 (UniProt - Evidence at protein level)

neXtProt

NX_O00763

Antibodypedia

ACACB antibodies
 

PROTEIN VIEW

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ACACB-001
 
ACACB-002
 
ACACB-004
 
ACACB-005
 
ACACB-201
 
ACACB-202
 
ACACB-203
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ACACB-001 ENSP00000341044
ENST00000338432
O00763
Show all »
Show » Show » 2458 276.5 Yes 0
ACACB-002 ENSP00000474680
ENST00000544726
Show » 155 17.6 No 0
ACACB-004 ENSP00000443281
ENST00000538526
F6QQI9
Show all »
Show » Show » 859 97.4 No 0
ACACB-005 ENSP00000443494
ENST00000539864
F5H5C3
Show all »
Show » 143 15.1 No 0
ACACB-201 ENSP00000367079
ENST00000377848
O00763
Show all »
Show » Show » 2458 276.5 Yes 0
ACACB-202 ENSP00000367085
ENST00000377854
F8W8T8
Show all »
Show » Show » 2388 268.1 Yes 0
ACACB-203 ENSP00000444075
ENST00000543201
F6QQI9
Show all »
Show » Show » 858 97.4 No 0