MAP2K7

GENE INFORMATION

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Gene name

MAP2K7 (HGNC Symbol)

Synonyms

Jnkk2, MKK7, PRKMK7

Description

Mitogen-activated protein kinase kinase 7 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found, but only one transcript variant has been supported and defined. [provided by RefSeq, Jul 2008]

Chromosome

19

Cytoband

p13.2

Chromosome location (bp)

7968728 - 7979363

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000076984 (version 75.37)

Entrez gene

5609

UniProt

O14733 (UniProt - Evidence at protein level)

neXtProt

NX_O14733

Antibodypedia

MAP2K7 antibodies
 

PROTEIN VIEW

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MAP2K7-001
 
MAP2K7-002
 
MAP2K7-003
 
MAP2K7-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MAP2K7-001 ENSP00000381068
ENST00000397981
O14733
Show all »
Show » Show » 426 48.2 No 0
MAP2K7-002 ENSP00000381066
ENST00000397979
O14733
Show all »
Show » Show » 419 47.5 No 0
MAP2K7-003 ENSP00000381070
ENST00000397983
O14733
Show all »
Show » Show » 435 49.1 No 0
MAP2K7-201 ENSP00000443946
ENST00000545011
F6WCX7
Show all »
Show » Show » 461 51.8 No 0