TOP2B

GENE INFORMATION

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Gene name

TOP2B

Synonyms

Description

topoisomerase (DNA) II beta 180kDa (HGNC Symbol)

Entrez gene summary

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. Alternative splicing of this gene results in two transcript variants; however, the second variant has not yet been fully described. [provided by RefSeq, Jul 2008]

Chromosome

3 (Chromosome progress)

Cytoband

p24.2

Chromosome location (bp)

25639475 - 25706398

Ensembl

ENSG00000077097 (version 73.37)

Entrez gene

7155

UniProt

Q02880 (UniProt - Evidence at protein level)

neXtProt

NX_Q02880

Antibodypedia

TOP2B antibodies
 

PROTEIN VIEW

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TOP2B-001
 
TOP2B-002
 
TOP2B-005
 
TOP2B-201
 
TOP2B-202
 
TOP2B-203
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TOP2B-001 ENSP00000396704
ENST00000435706
Q02880
Show all »
Show » Show » 1621 182.7 No 0
TOP2B-002 ENSP00000391112
ENST00000424225
E9PCY5
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Show » 1150 130.5 No 0
TOP2B-005 ENSP00000388216
ENST00000413971
H7BZ82
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Show » 70 8.2 No 0
TOP2B-201 ENSP00000264331
ENST00000264331
Q02880
Show all »
Show » Show » 1626 183.3 No 0
TOP2B-202 ENSP00000437352
ENST00000540199
B4DLV2
Show all »
Show » 478 53 No 0
TOP2B-203 ENSP00000446023
ENST00000542520
B4DLV2
Show all »
Show » 478 53 No 0