PAK3

GENE INFORMATION

? »

Gene name

PAK3 (HGNC Symbol)

Synonyms

bPAK, hPAK3, MRX30, MRX47

Description

p21 protein (Cdc42/Rac)-activated kinase 3 (HGNC Symbol)

Entrez gene summary

PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities. The protein encoded by this gene forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1 proteins which then catalyzes a variety of targets. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. Defects in this gene are the cause of non-syndromic mental retardation X-linked type 30 (MRX30), also called X-linked mental retardation type 47 (MRX47). Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Chromosome

X (Chromosome progress)

Cytoband

q23

Chromosome location (bp)

110187513 - 110464173

Ensembl

ENSG00000077264 (version 73.37)

Entrez gene

5063

UniProt

O75914 (UniProt - Evidence at protein level)

neXtProt

NX_O75914

Antibodypedia

PAK3 antibodies
 

PROTEIN VIEW

? »
 
 
 
PAK3-001
 
PAK3-002
 
PAK3-003
 
PAK3-006
 
PAK3-007
 
PAK3-201
 
PAK3-202
 
PAK3-203
 
PAK3-204
 
PAK3-205
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PAK3-001 ENSP00000361077
ENST00000372007
O75914
Show all »
Show » Show » 544 60.7 No 0
PAK3-002 ENSP00000361080
ENST00000372010
O75914
Show all »
Show » Show » 559 62.3 No 0
PAK3-003 ENSP00000405642
ENST00000429193
B1AKS5
Show all »
Show » Show » 181 20.2 No 0
PAK3-006 ENSP00000429113
ENST00000519681
O75914
Show all »
Show » Show » 565 62.9 No 0
PAK3-007 ENSP00000428921
ENST00000518291
O75914
Show all »
Show » Show » 580 64.5 No 0
PAK3-201 ENSP00000262836
ENST00000262836
O75914
Show all »
Show » Show » 559 62.3 No 0
PAK3-202 ENSP00000353864
ENST00000360648
O75914
Show all »
Show » Show » 580 64.5 No 0
PAK3-203 ENSP00000389172
ENST00000417227
O75914
Show all »
Show » Show » 565 62.9 No 0
PAK3-204 ENSP00000401982
ENST00000425146
O75914
Show all »
Show » Show » 544 60.7 No 0
PAK3-205 ENSP00000410853
ENST00000446737
O75914
Show all »
Show » Show » 544 60.7 No 0