CAPN6

GENE INFORMATION

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Gene name

CAPN6 (HGNC Symbol)

Synonyms

CalpM, CANPX, CAPNX

Description

calpain 6 (HGNC Symbol)

Entrez gene summary

Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is highly expressed in the placenta. Its C-terminal region lacks any homology to the calmodulin-like domain of other calpains. The protein lacks critical active site residues and thus is suggested to be proteolytically inactive. The protein may play a role in tumor formation by inhibiting apoptosis and promoting angiogenesis. [provided by RefSeq, Nov 2009]

Chromosome

X (Chromosome progress)

Cytoband

q23

Chromosome location (bp)

110488331 - 110513751

Ensembl

ENSG00000077274 (version 73.37)

Entrez gene

827

UniProt

Q9Y6Q1 (UniProt - Evidence at protein level)

neXtProt

NX_Q9Y6Q1

Antibodypedia

CAPN6 antibodies
 

PROTEIN VIEW

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CAPN6-001
 
CAPN6-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CAPN6-001 ENSP00000317214
ENST00000324068
Q9Y6Q1
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Show » Show » 641 74.6 No 0
CAPN6-201 ENSP00000441736
ENST00000541758
F5GWQ6
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Show » 386 45.1 No 0