ACTN2

GENE INFORMATION

? »

Gene name

ACTN2

Synonyms

Description

actinin, alpha 2 (HGNC Symbol)

Entrez gene summary

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013]

Chromosome

1 (Chromosome progress)

Cytoband

q43

Chromosome location (bp)

236849754 - 236927931

Ensembl

ENSG00000077522 (version 73.37)

Entrez gene

88

UniProt

P35609 (UniProt - Evidence at protein level)

neXtProt

NX_P35609

Antibodypedia

ACTN2 antibodies
 

PROTEIN VIEW

? »
 
 
 
ACTN2-001
 
ACTN2-201
 
ACTN2-202
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ACTN2-001 ENSP00000355537
ENST00000366578
P35609
Show all »
Show » Show » 894 103.9 No 0
ACTN2-201 ENSP00000443495
ENST00000542672
B2RCS5
Show all »
Show » Show » 894 103.9 No 0
ACTN2-202 ENSP00000438384
ENST00000546208
B7Z4P8
Show all »
Show » 388 44.6 No 0