The Human Protein Atlas

GENE INFORMATION

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Gene name	FGFR1 (HGNC Symbol)
Synonyms	BFGFR, CD331, CEK, FLG, FLT2, H2, H3, H4, H5, KAL2, N-SAM
Description	fibroblast growth factor receptor 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
Chromosome	8 (Chromosome progress)
Cytoband	p11.22
Chromosome location (bp)	38268656 - 38326352
Ensembl	ENSG00000077782 (version 69.37)
Entrez gene	2260
UniProt	P11362
neXtProt	NX_P11362
Antibodypedia	FGFR1 antibodies

PROTEIN VIEW

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FGFR1-001		FGFR1-002		FGFR1-003		FGFR1-004		FGFR1-008		FGFR1-009		FGFR1-010		FGFR1-011		FGFR1-012		FGFR1-015		FGFR1-016		FGFR1-019		FGFR1-020		FGFR1-027		FGFR1-028		FGFR1-036		FGFR1-037		FGFR1-038		FGFR1-039		FGFR1-201		FGFR1-202		FGFR1-203

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
FGFR1-001	ENSP00000380280 ENST00000397091	P11362 Show all » « Hide P11362 [Direct mapping] Fibroblast growth factor receptor 1 D3DSX2 [Target identity:47%; Query identity:100%] Fibroblast growth factor receptor 1 (Fms-related tyrosine kinase 2, Pfeiffer syndrome), isoform CRA_b E9PN14 [Target identity:16%; Query identity:100%] Fibroblast growth factor receptor 1 C9J205 [Target identity:13%; Query identity:100%] Fibroblast growth factor receptor 1	Show » « Hide Kinases Tyr protein kinases CD markers Candidate cancer biomarkers Enzymes Transferases Mutated genes in cancer Potential transmembrane proteins Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins 1TM proteins predicted by MDM Potentially secreted proteins Secreted proteins predicted by MDSP SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000165 [MAPKKK cascade] GO:0001501 [skeletal system development] GO:0001525 [angiogenesis] GO:0001657 [ureteric bud development] GO:0001701 [in utero embryonic development] GO:0001759 [organ induction] GO:0001764 [neuron migration] GO:0001948 [glycoprotein binding] GO:0002053 [positive regulation of mesenchymal cell proliferation] GO:0002062 [chondrocyte differentiation] GO:0004713 [protein tyrosine kinase activity] GO:0005007 [fibroblast growth factor-activated receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral to plasma membrane] GO:0006351 [transcription, DNA-dependent] GO:0006355 [regulation of transcription, DNA-dependent] GO:0006468 [protein phosphorylation] GO:0007411 [axon guidance] GO:0007605 [sensory perception of sound] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0010518 [positive regulation of phospholipase activity] GO:0010863 [positive regulation of phospholipase C activity] GO:0010976 [positive regulation of neuron projection development] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase cascade] GO:0016021 [integral to membrane] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0016477 [cell migration] GO:0017134 [fibroblast growth factor binding] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019827 [stem cell maintenance] GO:0021837 [motogenic signaling involved in postnatal olfactory bulb interneuron migration] GO:0021847 [ventricular zone neuroblast division] GO:0021954 [central nervous system neuron development] GO:0030326 [embryonic limb morphogenesis] GO:0030901 [midbrain development] GO:0031175 [neuron projection development] GO:0035607 [fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development] GO:0042472 [inner ear morphogenesis] GO:0042473 [outer ear morphogenesis] GO:0042474 [middle ear morphogenesis] GO:0042803 [protein homodimerization activity] GO:0043009 [chordate embryonic development] GO:0043066 [negative regulation of apoptotic process] GO:0043406 [positive regulation of MAP kinase activity] GO:0043410 [positive regulation of MAPK cascade] GO:0045595 [regulation of cell differentiation] GO:0045666 [positive regulation of neuron differentiation] GO:0045668 [negative regulation of osteoblast differentiation] GO:0045787 [positive regulation of cell cycle] GO:0046777 [protein autophosphorylation] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0048339 [paraxial mesoderm development] GO:0048378 [regulation of lateral mesodermal cell fate specification] GO:0048469 [cell maturation] GO:0048705 [skeletal system morphogenesis] GO:0048762 [mesenchymal cell differentiation] GO:0050839 [cell adhesion molecule binding] GO:0051930 [regulation of sensory perception of pain] GO:0060045 [positive regulation of cardiac muscle cell proliferation] GO:0060117 [auditory receptor cell development] GO:0060445 [branching involved in salivary gland morphogenesis] GO:0060484 [lung-associated mesenchyme development] GO:0060665 [regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling] GO:0072091 [regulation of stem cell proliferation]	820	91.6	Yes	1
FGFR1-002	ENSP00000432972 ENST00000532791	P11362 Show all » « Hide P11362 [Direct mapping] Fibroblast growth factor receptor 1 D3DSX2 [Target identity:47%; Query identity:100%] Fibroblast growth factor receptor 1 (Fms-related tyrosine kinase 2, Pfeiffer syndrome), isoform CRA_b E9PNM3 [Target identity:36%; Query identity:100%] Fibroblast growth factor receptor 1 E9PN14 [Target identity:16%; Query identity:100%] Fibroblast growth factor receptor 1 C9J205 [Target identity:13%; Query identity:100%] Fibroblast growth factor receptor 1	Show » « Hide Kinases Tyr protein kinases CD markers Candidate cancer biomarkers Enzymes Transferases Mutated genes in cancer Potential transmembrane proteins Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins 1TM proteins predicted by MDM Potentially secreted proteins Secreted proteins predicted by MDSP SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000165 [MAPKKK cascade] GO:0001501 [skeletal system development] GO:0001525 [angiogenesis] GO:0001657 [ureteric bud development] GO:0001701 [in utero embryonic development] GO:0001759 [organ induction] GO:0001764 [neuron migration] GO:0001948 [glycoprotein binding] GO:0002053 [positive regulation of mesenchymal cell proliferation] GO:0002062 [chondrocyte differentiation] GO:0004713 [protein tyrosine kinase activity] GO:0005007 [fibroblast growth factor-activated receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral to plasma membrane] GO:0006351 [transcription, DNA-dependent] GO:0006355 [regulation of transcription, DNA-dependent] GO:0006468 [protein phosphorylation] GO:0007411 [axon guidance] GO:0007605 [sensory perception of sound] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0010518 [positive regulation of phospholipase activity] GO:0010863 [positive regulation of phospholipase C activity] GO:0010976 [positive regulation of neuron projection development] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase cascade] GO:0016021 [integral to membrane] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0016477 [cell migration] GO:0017134 [fibroblast growth factor binding] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019827 [stem cell maintenance] GO:0021837 [motogenic signaling involved in postnatal olfactory bulb interneuron migration] GO:0021847 [ventricular zone neuroblast division] GO:0021954 [central nervous system neuron development] GO:0030326 [embryonic limb morphogenesis] GO:0030901 [midbrain development] GO:0031175 [neuron projection development] GO:0035607 [fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development] GO:0042472 [inner ear morphogenesis] GO:0042473 [outer ear morphogenesis] GO:0042474 [middle ear morphogenesis] GO:0042803 [protein homodimerization activity] GO:0043009 [chordate embryonic development] GO:0043066 [negative regulation of apoptotic process] GO:0043406 [positive regulation of MAP kinase activity] GO:0043410 [positive regulation of MAPK cascade] GO:0045595 [regulation of cell differentiation] GO:0045666 [positive regulation of neuron differentiation] GO:0045668 [negative regulation of osteoblast differentiation] GO:0045787 [positive regulation of cell cycle] GO:0046777 [protein autophosphorylation] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0048339 [paraxial mesoderm development] GO:0048378 [regulation of lateral mesodermal cell fate specification] GO:0048469 [cell maturation] GO:0048705 [skeletal system morphogenesis] GO:0048762 [mesenchymal cell differentiation] GO:0050839 [cell adhesion molecule binding] GO:0051930 [regulation of sensory perception of pain] GO:0060045 [positive regulation of cardiac muscle cell proliferation] GO:0060117 [auditory receptor cell development] GO:0060445 [branching involved in salivary gland morphogenesis] GO:0060484 [lung-associated mesenchyme development] GO:0060665 [regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling] GO:0072091 [regulation of stem cell proliferation]	820	91.7	Yes	1
FGFR1-003	ENSP00000337247 ENST00000335922	P11362 Show all » « Hide P11362 [Direct mapping] Fibroblast growth factor receptor 1 D3DSX2 [Target identity:47%; Query identity:100%] Fibroblast growth factor receptor 1 (Fms-related tyrosine kinase 2, Pfeiffer syndrome), isoform CRA_b E9PN14 [Target identity:17%; Query identity:100%] Fibroblast growth factor receptor 1	Show » « Hide Kinases Tyr protein kinases CD markers Candidate cancer biomarkers Enzymes Transferases Mutated genes in cancer Potential transmembrane proteins Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins 1TM proteins predicted by MDM Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000165 [MAPKKK cascade] GO:0001501 [skeletal system development] GO:0001525 [angiogenesis] GO:0001657 [ureteric bud development] GO:0001701 [in utero embryonic development] GO:0001759 [organ induction] GO:0001764 [neuron migration] GO:0001948 [glycoprotein binding] GO:0002053 [positive regulation of mesenchymal cell proliferation] GO:0002062 [chondrocyte differentiation] GO:0004713 [protein tyrosine kinase activity] GO:0005007 [fibroblast growth factor-activated receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral to plasma membrane] GO:0006351 [transcription, DNA-dependent] GO:0006355 [regulation of transcription, DNA-dependent] GO:0006468 [protein phosphorylation] GO:0007411 [axon guidance] GO:0007605 [sensory perception of sound] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0010518 [positive regulation of phospholipase activity] GO:0010863 [positive regulation of phospholipase C activity] GO:0010976 [positive regulation of neuron projection development] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase cascade] GO:0016021 [integral to membrane] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0016477 [cell migration] GO:0017134 [fibroblast growth factor binding] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019827 [stem cell maintenance] GO:0021837 [motogenic signaling involved in postnatal olfactory bulb interneuron migration] GO:0021847 [ventricular zone neuroblast division] GO:0021954 [central nervous system neuron development] GO:0030326 [embryonic limb morphogenesis] GO:0030901 [midbrain development] GO:0031175 [neuron projection development] GO:0035607 [fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development] GO:0042472 [inner ear morphogenesis] GO:0042473 [outer ear morphogenesis] GO:0042474 [middle ear morphogenesis] GO:0042803 [protein homodimerization activity] GO:0043009 [chordate embryonic development] GO:0043066 [negative regulation of apoptotic process] GO:0043406 [positive regulation of MAP kinase activity] GO:0043410 [positive regulation of MAPK cascade] GO:0045595 [regulation of cell differentiation] GO:0045666 [positive regulation of neuron differentiation] GO:0045668 [negative regulation of osteoblast differentiation] GO:0045787 [positive regulation of cell cycle] GO:0046777 [protein autophosphorylation] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0048339 [paraxial mesoderm development] GO:0048378 [regulation of lateral mesodermal cell fate specification] GO:0048469 [cell maturation] GO:0048705 [skeletal system morphogenesis] GO:0048762 [mesenchymal cell differentiation] GO:0050839 [cell adhesion molecule binding] GO:0051930 [regulation of sensory perception of pain] GO:0060045 [positive regulation of cardiac muscle cell proliferation] GO:0060117 [auditory receptor cell development] GO:0060445 [branching involved in salivary gland morphogenesis] GO:0060484 [lung-associated mesenchyme development] GO:0060665 [regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling] GO:0072091 [regulation of stem cell proliferation]	812	90.6	No	1
FGFR1-004	ENSP00000348537 ENST00000356207	P11362 Show all » « Hide P11362 [Direct mapping] Fibroblast growth factor receptor 1 D3DSX2 [Target identity:52%; Query identity:100%] Fibroblast growth factor receptor 1 (Fms-related tyrosine kinase 2, Pfeiffer syndrome), isoform CRA_b E9PKV7 [Target identity:19%; Query identity:100%] Fibroblast growth factor receptor 1 E9PN14 [Target identity:18%; Query identity:100%] Fibroblast growth factor receptor 1 C9J1L5 [Target identity:7%; Query identity:100%] Fibroblast growth factor receptor 1	Show » « Hide Kinases Tyr protein kinases CD markers Candidate cancer biomarkers Enzymes Transferases Mutated genes in cancer Potential transmembrane proteins Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins 1TM proteins predicted by MDM Potentially secreted proteins Secreted proteins predicted by MDSP SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000165 [MAPKKK cascade] GO:0001501 [skeletal system development] GO:0001525 [angiogenesis] GO:0001657 [ureteric bud development] GO:0001701 [in utero embryonic development] GO:0001759 [organ induction] GO:0001764 [neuron migration] GO:0001948 [glycoprotein binding] GO:0002053 [positive regulation of mesenchymal cell proliferation] GO:0002062 [chondrocyte differentiation] GO:0004713 [protein tyrosine kinase activity] GO:0005007 [fibroblast growth factor-activated receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral to plasma membrane] GO:0006351 [transcription, DNA-dependent] GO:0006355 [regulation of transcription, DNA-dependent] GO:0006468 [protein phosphorylation] GO:0007411 [axon guidance] GO:0007605 [sensory perception of sound] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0010518 [positive regulation of phospholipase activity] GO:0010863 [positive regulation of phospholipase C activity] GO:0010976 [positive regulation of neuron projection development] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase cascade] GO:0016021 [integral to membrane] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0016477 [cell migration] GO:0017134 [fibroblast growth factor binding] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019827 [stem cell maintenance] GO:0021837 [motogenic signaling involved in postnatal olfactory bulb interneuron migration] GO:0021847 [ventricular zone neuroblast division] GO:0021954 [central nervous system neuron development] GO:0030326 [embryonic limb morphogenesis] GO:0030901 [midbrain development] GO:0031175 [neuron projection development] GO:0035607 [fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development] GO:0042472 [inner ear morphogenesis] GO:0042473 [outer ear morphogenesis] GO:0042474 [middle ear morphogenesis] GO:0042803 [protein homodimerization activity] GO:0043009 [chordate embryonic development] GO:0043066 [negative regulation of apoptotic process] GO:0043406 [positive regulation of MAP kinase activity] GO:0043410 [positive regulation of MAPK cascade] GO:0045595 [regulation of cell differentiation] GO:0045666 [positive regulation of neuron differentiation] GO:0045668 [negative regulation of osteoblast differentiation] GO:0045787 [positive regulation of cell cycle] GO:0046777 [protein autophosphorylation] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0048339 [paraxial mesoderm development] GO:0048378 [regulation of lateral mesodermal cell fate specification] GO:0048469 [cell maturation] GO:0048705 [skeletal system morphogenesis] GO:0048762 [mesenchymal cell differentiation] GO:0050839 [cell adhesion molecule binding] GO:0051930 [regulation of sensory perception of pain] GO:0060045 [positive regulation of cardiac muscle cell proliferation] GO:0060117 [auditory receptor cell development] GO:0060445 [branching involved in salivary gland morphogenesis] GO:0060484 [lung-associated mesenchyme development] GO:0060665 [regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling] GO:0072091 [regulation of stem cell proliferation]	733	82.2	Yes	1
FGFR1-008	ENSP00000327229 ENST00000326324	P11362 Show all » « Hide P11362 [Direct mapping] Fibroblast growth factor receptor 1 D3DSX2 [Target identity:52%; Query identity:100%] Fibroblast growth factor receptor 1 (Fms-related tyrosine kinase 2, Pfeiffer syndrome), isoform CRA_b E9PKF2 [Target identity:19%; Query identity:100%] Fibroblast growth factor receptor 1 E9PN14 [Target identity:19%; Query identity:100%] Fibroblast growth factor receptor 1 E9PQ40 [Target identity:11%; Query identity:100%] Fibroblast growth factor receptor 1 C9J1L5 [Target identity:7%; Query identity:100%] Fibroblast growth factor receptor 1	Show » « Hide Kinases Tyr protein kinases CD markers Candidate cancer biomarkers Enzymes Transferases Mutated genes in cancer Potential transmembrane proteins Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins 1TM proteins predicted by MDM Potentially secreted proteins Secreted proteins predicted by MDSP SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000165 [MAPKKK cascade] GO:0001501 [skeletal system development] GO:0001525 [angiogenesis] GO:0001657 [ureteric bud development] GO:0001701 [in utero embryonic development] GO:0001759 [organ induction] GO:0001764 [neuron migration] GO:0001948 [glycoprotein binding] GO:0002053 [positive regulation of mesenchymal cell proliferation] GO:0002062 [chondrocyte differentiation] GO:0004713 [protein tyrosine kinase activity] GO:0005007 [fibroblast growth factor-activated receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral to plasma membrane] GO:0006351 [transcription, DNA-dependent] GO:0006355 [regulation of transcription, DNA-dependent] GO:0006468 [protein phosphorylation] GO:0007411 [axon guidance] GO:0007605 [sensory perception of sound] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0010518 [positive regulation of phospholipase activity] GO:0010863 [positive regulation of phospholipase C activity] GO:0010976 [positive regulation of neuron projection development] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase cascade] GO:0016021 [integral to membrane] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0016477 [cell migration] GO:0017134 [fibroblast growth factor binding] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019827 [stem cell maintenance] GO:0021837 [motogenic signaling involved in postnatal olfactory bulb interneuron migration] GO:0021847 [ventricular zone neuroblast division] GO:0021954 [central nervous system neuron development] GO:0030326 [embryonic limb morphogenesis] GO:0030901 [midbrain development] GO:0031175 [neuron projection development] GO:0035607 [fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development] GO:0042472 [inner ear morphogenesis] GO:0042473 [outer ear morphogenesis] GO:0042474 [middle ear morphogenesis] GO:0042803 [protein homodimerization activity] GO:0043009 [chordate embryonic development] GO:0043066 [negative regulation of apoptotic process] GO:0043406 [positive regulation of MAP kinase activity] GO:0043410 [positive regulation of MAPK cascade] GO:0045595 [regulation of cell differentiation] GO:0045666 [positive regulation of neuron differentiation] GO:0045668 [negative regulation of osteoblast differentiation] GO:0045787 [positive regulation of cell cycle] GO:0046777 [protein autophosphorylation] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0048339 [paraxial mesoderm development] GO:0048378 [regulation of lateral mesodermal cell fate specification] GO:0048469 [cell maturation] GO:0048705 [skeletal system morphogenesis] GO:0048762 [mesenchymal cell differentiation] GO:0050839 [cell adhesion molecule binding] GO:0051930 [regulation of sensory perception of pain] GO:0060045 [positive regulation of cardiac muscle cell proliferation] GO:0060117 [auditory receptor cell development] GO:0060445 [branching involved in salivary gland morphogenesis] GO:0060484 [lung-associated mesenchyme development] GO:0060665 [regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling] GO:0072091 [regulation of stem cell proliferation]	731	81.9	Yes	1
FGFR1-009	ENSP00000433163 ENST00000484370	P11362 Show all » « Hide P11362 [Direct mapping] Fibroblast growth factor receptor 1 C9J205 [Target identity:71%; Query identity:100%] Fibroblast growth factor receptor 1	Show » « Hide Kinases Tyr protein kinases CD markers Candidate cancer biomarkers Enzymes Transferases Mutated genes in cancer Potential transmembrane proteins MEMSAT3 predicted membrane proteins Potentially secreted proteins Secreted proteins predicted by MDSP SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000165 [MAPKKK cascade] GO:0001501 [skeletal system development] GO:0001525 [angiogenesis] GO:0001657 [ureteric bud development] GO:0001701 [in utero embryonic development] GO:0001759 [organ induction] GO:0001764 [neuron migration] GO:0001948 [glycoprotein binding] GO:0002053 [positive regulation of mesenchymal cell proliferation] GO:0002062 [chondrocyte differentiation] GO:0004713 [protein tyrosine kinase activity] GO:0005007 [fibroblast growth factor-activated receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral to plasma membrane] GO:0006351 [transcription, DNA-dependent] GO:0006355 [regulation of transcription, DNA-dependent] GO:0006468 [protein phosphorylation] GO:0007411 [axon guidance] GO:0007605 [sensory perception of sound] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0010518 [positive regulation of phospholipase activity] GO:0010863 [positive regulation of phospholipase C activity] GO:0010976 [positive regulation of neuron projection development] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase cascade] GO:0016021 [integral to membrane] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0016477 [cell migration] GO:0017134 [fibroblast growth factor binding] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019827 [stem cell maintenance] GO:0021837 [motogenic signaling involved in postnatal olfactory bulb interneuron migration] GO:0021847 [ventricular zone neuroblast division] GO:0021954 [central nervous system neuron development] GO:0030326 [embryonic limb morphogenesis] GO:0030901 [midbrain development] GO:0031175 [neuron projection development] GO:0035607 [fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development] GO:0042472 [inner ear morphogenesis] GO:0042473 [outer ear morphogenesis] GO:0042474 [middle ear morphogenesis] GO:0042803 [protein homodimerization activity] GO:0043009 [chordate embryonic development] GO:0043066 [negative regulation of apoptotic process] GO:0043406 [positive regulation of MAP kinase activity] GO:0043410 [positive regulation of MAPK cascade] GO:0045595 [regulation of cell differentiation] GO:0045666 [positive regulation of neuron differentiation] GO:0045668 [negative regulation of osteoblast differentiation] GO:0045787 [positive regulation of cell cycle] GO:0046777 [protein autophosphorylation] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0048339 [paraxial mesoderm development] GO:0048378 [regulation of lateral mesodermal cell fate specification] GO:0048469 [cell maturation] GO:0048705 [skeletal system morphogenesis] GO:0048762 [mesenchymal cell differentiation] GO:0050839 [cell adhesion molecule binding] GO:0051930 [regulation of sensory perception of pain] GO:0060045 [positive regulation of cardiac muscle cell proliferation] GO:0060117 [auditory receptor cell development] GO:0060445 [branching involved in salivary gland morphogenesis] GO:0060484 [lung-associated mesenchyme development] GO:0060665 [regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling] GO:0072091 [regulation of stem cell proliferation]	150	16.5	Yes	0
FGFR1-010	ENSP00000435254 ENST00000487647	E9PKX3 Show all » « Hide E9PKX3 [Target identity:100%; Query identity:100%] Fibroblast growth factor receptor 1	Show » « Hide Mutated genes in cancer Potential transmembrane proteins MEMSAT3 predicted membrane proteins Potentially secreted proteins Secreted proteins predicted by MDSP SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins		61	6.8	Yes	0
FGFR1-011	ENSP00000380292 ENST00000397103	E7EU09 Show all » « Hide E7EU09 [Target identity:100%; Query identity:100%] Fibroblast growth factor receptor D3DSX2 [Target identity:52%; Query identity:100%] Fibroblast growth factor receptor 1 (Fms-related tyrosine kinase 2, Pfeiffer syndrome), isoform CRA_b E9PKF2 [Target identity:19%; Query identity:100%] Fibroblast growth factor receptor 1 E9PN14 [Target identity:18%; Query identity:100%] Fibroblast growth factor receptor 1 E9PQ40 [Target identity:11%; Query identity:100%] Fibroblast growth factor receptor 1 C9J1L5 [Target identity:7%; Query identity:100%] Fibroblast growth factor receptor 1	Show » « Hide Mutated genes in cancer Potential transmembrane proteins Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins 1TM proteins predicted by MDM Potentially secreted proteins Secreted proteins predicted by MDSP SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001525 [angiogenesis] GO:0001657 [ureteric bud development] GO:0001701 [in utero embryonic development] GO:0001759 [organ induction] GO:0001948 [glycoprotein binding] GO:0002053 [positive regulation of mesenchymal cell proliferation] GO:0002062 [chondrocyte differentiation] GO:0005007 [fibroblast growth factor-activated receptor activity] GO:0005524 [ATP binding] GO:0007605 [sensory perception of sound] GO:0008284 [positive regulation of cell proliferation] GO:0010976 [positive regulation of neuron projection development] GO:0016021 [integral to membrane] GO:0017134 [fibroblast growth factor binding] GO:0019827 [stem cell maintenance] GO:0021837 [motogenic signaling involved in postnatal olfactory bulb interneuron migration] GO:0021847 [ventricular zone neuroblast division] GO:0021954 [central nervous system neuron development] GO:0030326 [embryonic limb morphogenesis] GO:0030901 [midbrain development] GO:0031175 [neuron projection development] GO:0035607 [fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development] GO:0042472 [inner ear morphogenesis] GO:0042473 [outer ear morphogenesis] GO:0042474 [middle ear morphogenesis] GO:0043066 [negative regulation of apoptotic process] GO:0045668 [negative regulation of osteoblast differentiation] GO:0045787 [positive regulation of cell cycle] GO:0048339 [paraxial mesoderm development] GO:0048378 [regulation of lateral mesodermal cell fate specification] GO:0048469 [cell maturation] GO:0048762 [mesenchymal cell differentiation] GO:0050839 [cell adhesion molecule binding] GO:0051930 [regulation of sensory perception of pain] GO:0060045 [positive regulation of cardiac muscle cell proliferation] GO:0060117 [auditory receptor cell development] GO:0060445 [branching involved in salivary gland morphogenesis] GO:0060484 [lung-associated mesenchyme development] GO:0060665 [regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling] GO:0072091 [regulation of stem cell proliferation]	733	82	Yes	1
FGFR1-012	ENSP00000380302 ENST00000397113	P11362 Show all » « Hide P11362 [Direct mapping] Fibroblast growth factor receptor 1 D3DSX2 [Target identity:47%; Query identity:100%] Fibroblast growth factor receptor 1 (Fms-related tyrosine kinase 2, Pfeiffer syndrome), isoform CRA_b E9PN14 [Target identity:16%; Query identity:100%] Fibroblast growth factor receptor 1 C9J205 [Target identity:13%; Query identity:100%] Fibroblast growth factor receptor 1	Show » « Hide Kinases Tyr protein kinases CD markers Candidate cancer biomarkers Enzymes Transferases Mutated genes in cancer Potential transmembrane proteins Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins 1TM proteins predicted by MDM Potentially secreted proteins Secreted proteins predicted by MDSP SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000165 [MAPKKK cascade] GO:0001501 [skeletal system development] GO:0001525 [angiogenesis] GO:0001657 [ureteric bud development] GO:0001701 [in utero embryonic development] GO:0001759 [organ induction] GO:0001764 [neuron migration] GO:0001948 [glycoprotein binding] GO:0002053 [positive regulation of mesenchymal cell proliferation] GO:0002062 [chondrocyte differentiation] GO:0004713 [protein tyrosine kinase activity] GO:0005007 [fibroblast growth factor-activated receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral to plasma membrane] GO:0006351 [transcription, DNA-dependent] GO:0006355 [regulation of transcription, DNA-dependent] GO:0006468 [protein phosphorylation] GO:0007411 [axon guidance] GO:0007605 [sensory perception of sound] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0010518 [positive regulation of phospholipase activity] GO:0010863 [positive regulation of phospholipase C activity] GO:0010976 [positive regulation of neuron projection development] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase cascade] GO:0016021 [integral to membrane] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0016477 [cell migration] GO:0017134 [fibroblast growth factor binding] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019827 [stem cell maintenance] GO:0021837 [motogenic signaling involved in postnatal olfactory bulb interneuron migration] GO:0021847 [ventricular zone neuroblast division] GO:0021954 [central nervous system neuron development] GO:0030326 [embryonic limb morphogenesis] GO:0030901 [midbrain development] GO:0031175 [neuron projection development] GO:0035607 [fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development] GO:0042472 [inner ear morphogenesis] GO:0042473 [outer ear morphogenesis] GO:0042474 [middle ear morphogenesis] GO:0042803 [protein homodimerization activity] GO:0043009 [chordate embryonic development] GO:0043066 [negative regulation of apoptotic process] GO:0043406 [positive regulation of MAP kinase activity] GO:0043410 [positive regulation of MAPK cascade] GO:0045595 [regulation of cell differentiation] GO:0045666 [positive regulation of neuron differentiation] GO:0045668 [negative regulation of osteoblast differentiation] GO:0045787 [positive regulation of cell cycle] GO:0046777 [protein autophosphorylation] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0048339 [paraxial mesoderm development] GO:0048378 [regulation of lateral mesodermal cell fate specification] GO:0048469 [cell maturation] GO:0048705 [skeletal system morphogenesis] GO:0048762 [mesenchymal cell differentiation] GO:0050839 [cell adhesion molecule binding] GO:0051930 [regulation of sensory perception of pain] GO:0060045 [positive regulation of cardiac muscle cell proliferation] GO:0060117 [auditory receptor cell development] GO:0060445 [branching involved in salivary gland morphogenesis] GO:0060484 [lung-associated mesenchyme development] GO:0060665 [regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling] GO:0072091 [regulation of stem cell proliferation]	820	91.6	Yes	1
FGFR1-015	ENSP00000400708 ENST00000413133	C9J205 Show all » « Hide C9J205 [Target identity:100%; Query identity:100%] Fibroblast growth factor receptor 1	Show » « Hide Mutated genes in cancer Potential transmembrane proteins MEMSAT3 predicted membrane proteins Potentially secreted proteins Secreted proteins predicted by MDSP SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001525 [angiogenesis] GO:0001657 [ureteric bud development] GO:0001701 [in utero embryonic development] GO:0001759 [organ induction] GO:0001948 [glycoprotein binding] GO:0002053 [positive regulation of mesenchymal cell proliferation] GO:0002062 [chondrocyte differentiation] GO:0005007 [fibroblast growth factor-activated receptor activity] GO:0007605 [sensory perception of sound] GO:0010976 [positive regulation of neuron projection development] GO:0017134 [fibroblast growth factor binding] GO:0019827 [stem cell maintenance] GO:0021837 [motogenic signaling involved in postnatal olfactory bulb interneuron migration] GO:0021847 [ventricular zone neuroblast division] GO:0021954 [central nervous system neuron development] GO:0030326 [embryonic limb morphogenesis] GO:0030901 [midbrain development] GO:0031175 [neuron projection development] GO:0035607 [fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development] GO:0042472 [inner ear morphogenesis] GO:0042473 [outer ear morphogenesis] GO:0042474 [middle ear morphogenesis] GO:0043066 [negative regulation of apoptotic process] GO:0045668 [negative regulation of osteoblast differentiation] GO:0045787 [positive regulation of cell cycle] GO:0048339 [paraxial mesoderm development] GO:0048378 [regulation of lateral mesodermal cell fate specification] GO:0048469 [cell maturation] GO:0048762 [mesenchymal cell differentiation] GO:0050839 [cell adhesion molecule binding] GO:0051930 [regulation of sensory perception of pain] GO:0060045 [positive regulation of cardiac muscle cell proliferation] GO:0060117 [auditory receptor cell development] GO:0060445 [branching involved in salivary gland morphogenesis] GO:0060484 [lung-associated mesenchyme development] GO:0060665 [regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling] GO:0072091 [regulation of stem cell proliferation]	107	11.9	Yes	0
FGFR1-016	ENSP00000392645 ENST00000434187	C9J1L5 Show all » « Hide C9J1L5 [Target identity:100%; Query identity:100%] Fibroblast growth factor receptor 1	Show » « Hide Mutated genes in cancer Potential transmembrane proteins MEMSAT3 predicted membrane proteins Potentially secreted proteins Secreted proteins predicted by MDSP SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins		55	6.2	Yes	0
FGFR1-019	ENSP00000398318 ENST00000440174		Show » « Hide Mutated genes in cancer		1	0.1	No	0
FGFR1-020	ENSP00000380297 ENST00000397108	P11362 Show all » « Hide P11362 [Direct mapping] Fibroblast growth factor receptor 1 D3DSX2 [Target identity:47%; Query identity:100%] Fibroblast growth factor receptor 1 (Fms-related tyrosine kinase 2, Pfeiffer syndrome), isoform CRA_b E9PN14 [Target identity:16%; Query identity:100%] Fibroblast growth factor receptor 1 C9J205 [Target identity:13%; Query identity:100%] Fibroblast growth factor receptor 1	Show » « Hide Kinases Tyr protein kinases CD markers Candidate cancer biomarkers Enzymes Transferases Mutated genes in cancer Potential transmembrane proteins Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins 1TM proteins predicted by MDM Potentially secreted proteins Secreted proteins predicted by MDSP SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000165 [MAPKKK cascade] GO:0001501 [skeletal system development] GO:0001525 [angiogenesis] GO:0001657 [ureteric bud development] GO:0001701 [in utero embryonic development] GO:0001759 [organ induction] GO:0001764 [neuron migration] GO:0001948 [glycoprotein binding] GO:0002053 [positive regulation of mesenchymal cell proliferation] GO:0002062 [chondrocyte differentiation] GO:0004713 [protein tyrosine kinase activity] GO:0005007 [fibroblast growth factor-activated receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral to plasma membrane] GO:0006351 [transcription, DNA-dependent] GO:0006355 [regulation of transcription, DNA-dependent] GO:0006468 [protein phosphorylation] GO:0007411 [axon guidance] GO:0007605 [sensory perception of sound] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0010518 [positive regulation of phospholipase activity] GO:0010863 [positive regulation of phospholipase C activity] GO:0010976 [positive regulation of neuron projection development] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase cascade] GO:0016021 [integral to membrane] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0016477 [cell migration] GO:0017134 [fibroblast growth factor binding] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019827 [stem cell maintenance] GO:0021837 [motogenic signaling involved in postnatal olfactory bulb interneuron migration] GO:0021847 [ventricular zone neuroblast division] GO:0021954 [central nervous system neuron development] GO:0030326 [embryonic limb morphogenesis] GO:0030901 [midbrain development] GO:0031175 [neuron projection development] GO:0035607 [fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development] GO:0042472 [inner ear morphogenesis] GO:0042473 [outer ear morphogenesis] GO:0042474 [middle ear morphogenesis] GO:0042803 [protein homodimerization activity] GO:0043009 [chordate embryonic development] GO:0043066 [negative regulation of apoptotic process] GO:0043406 [positive regulation of MAP kinase activity] GO:0043410 [positive regulation of MAPK cascade] GO:0045595 [regulation of cell differentiation] GO:0045666 [positive regulation of neuron differentiation] GO:0045668 [negative regulation of osteoblast differentiation] GO:0045787 [positive regulation of cell cycle] GO:0046777 [protein autophosphorylation] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0048339 [paraxial mesoderm development] GO:0048378 [regulation of lateral mesodermal cell fate specification] GO:0048469 [cell maturation] GO:0048705 [skeletal system morphogenesis] GO:0048762 [mesenchymal cell differentiation] GO:0050839 [cell adhesion molecule binding] GO:0051930 [regulation of sensory perception of pain] GO:0060045 [positive regulation of cardiac muscle cell proliferation] GO:0060117 [auditory receptor cell development] GO:0060445 [branching involved in salivary gland morphogenesis] GO:0060484 [lung-associated mesenchyme development] GO:0060665 [regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling] GO:0072091 [regulation of stem cell proliferation]	820	91.6	Yes	1
FGFR1-027	ENSP00000434473 ENST00000530568	E9PQ40 Show all » « Hide E9PQ40 [Target identity:100%; Query identity:100%] Fibroblast growth factor receptor 1 C9J1L5 [Target identity:64%; Query identity:100%] Fibroblast growth factor receptor 1	Show » « Hide Mutated genes in cancer Potential transmembrane proteins MEMSAT3 predicted membrane proteins Potentially secreted proteins Secreted proteins predicted by MDSP SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins		85	9.5	Yes	0
FGFR1-028	ENSP00000434869 ENST00000533668	E9PN14 Show all » « Hide E9PN14 [Target identity:100%; Query identity:100%] Fibroblast growth factor receptor 1	Show » « Hide Mutated genes in cancer	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001525 [angiogenesis] GO:0001657 [ureteric bud development] GO:0001701 [in utero embryonic development] GO:0001759 [organ induction] GO:0001948 [glycoprotein binding] GO:0002053 [positive regulation of mesenchymal cell proliferation] GO:0002062 [chondrocyte differentiation] GO:0005007 [fibroblast growth factor-activated receptor activity] GO:0007605 [sensory perception of sound] GO:0010976 [positive regulation of neuron projection development] GO:0017134 [fibroblast growth factor binding] GO:0019827 [stem cell maintenance] GO:0021837 [motogenic signaling involved in postnatal olfactory bulb interneuron migration] GO:0021847 [ventricular zone neuroblast division] GO:0021954 [central nervous system neuron development] GO:0030326 [embryonic limb morphogenesis] GO:0030901 [midbrain development] GO:0031175 [neuron projection development] GO:0035607 [fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development] GO:0042472 [inner ear morphogenesis] GO:0042473 [outer ear morphogenesis] GO:0042474 [middle ear morphogenesis] GO:0043066 [negative regulation of apoptotic process] GO:0045668 [negative regulation of osteoblast differentiation] GO:0045787 [positive regulation of cell cycle] GO:0048339 [paraxial mesoderm development] GO:0048378 [regulation of lateral mesodermal cell fate specification] GO:0048469 [cell maturation] GO:0048762 [mesenchymal cell differentiation] GO:0050839 [cell adhesion molecule binding] GO:0051930 [regulation of sensory perception of pain] GO:0060045 [positive regulation of cardiac muscle cell proliferation] GO:0060117 [auditory receptor cell development] GO:0060445 [branching involved in salivary gland morphogenesis] GO:0060484 [lung-associated mesenchyme development] GO:0060665 [regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling] GO:0072091 [regulation of stem cell proliferation]	139	15.7	No	0
FGFR1-036	ENSP00000434712 ENST00000525001	E9PNM3 Show all » « Hide E9PNM3 [Target identity:100%; Query identity:100%] Fibroblast growth factor receptor 1 C9J205 [Target identity:35%; Query identity:100%] Fibroblast growth factor receptor 1	Show » « Hide Mutated genes in cancer Potential transmembrane proteins MEMSAT3 predicted membrane proteins Potentially secreted proteins Secreted proteins predicted by MDSP SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001525 [angiogenesis] GO:0001657 [ureteric bud development] GO:0001701 [in utero embryonic development] GO:0001759 [organ induction] GO:0001948 [glycoprotein binding] GO:0002053 [positive regulation of mesenchymal cell proliferation] GO:0002062 [chondrocyte differentiation] GO:0005007 [fibroblast growth factor-activated receptor activity] GO:0007605 [sensory perception of sound] GO:0010976 [positive regulation of neuron projection development] GO:0017134 [fibroblast growth factor binding] GO:0019827 [stem cell maintenance] GO:0021837 [motogenic signaling involved in postnatal olfactory bulb interneuron migration] GO:0021847 [ventricular zone neuroblast division] GO:0021954 [central nervous system neuron development] GO:0030326 [embryonic limb morphogenesis] GO:0030901 [midbrain development] GO:0031175 [neuron projection development] GO:0035607 [fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development] GO:0042472 [inner ear morphogenesis] GO:0042473 [outer ear morphogenesis] GO:0042474 [middle ear morphogenesis] GO:0043066 [negative regulation of apoptotic process] GO:0045668 [negative regulation of osteoblast differentiation] GO:0045787 [positive regulation of cell cycle] GO:0048339 [paraxial mesoderm development] GO:0048378 [regulation of lateral mesodermal cell fate specification] GO:0048469 [cell maturation] GO:0048762 [mesenchymal cell differentiation] GO:0050839 [cell adhesion molecule binding] GO:0051930 [regulation of sensory perception of pain] GO:0060045 [positive regulation of cardiac muscle cell proliferation] GO:0060117 [auditory receptor cell development] GO:0060445 [branching involved in salivary gland morphogenesis] GO:0060484 [lung-associated mesenchyme development] GO:0060665 [regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling] GO:0072091 [regulation of stem cell proliferation]	298	33.3	Yes	0
FGFR1-037	ENSP00000435283 ENST00000529552	E9PKV7 Show all » « Hide E9PKV7 [Target identity:100%; Query identity:100%] Fibroblast growth factor receptor 1 C9J1L5 [Target identity:38%; Query identity:100%] Fibroblast growth factor receptor 1	Show » « Hide Mutated genes in cancer Potential transmembrane proteins MEMSAT3 predicted membrane proteins Potentially secreted proteins Secreted proteins predicted by MDSP SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins		142	16	Yes	0
FGFR1-038	ENSP00000433569 ENST00000526742	E9PKF2 Show all » « Hide E9PKF2 [Target identity:100%; Query identity:100%] Fibroblast growth factor receptor 1 E9PQ40 [Target identity:58%; Query identity:100%] Fibroblast growth factor receptor 1 C9J1L5 [Target identity:37%; Query identity:100%] Fibroblast growth factor receptor 1	Show » « Hide Mutated genes in cancer Potential transmembrane proteins MEMSAT3 predicted membrane proteins Potentially secreted proteins Secreted proteins predicted by MDSP SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins		145	16.4	Yes	0
FGFR1-039	ENSP00000434800 ENST00000531196	H0YE20 Show all » « Hide H0YE20 [Target identity:100%; Query identity:100%] Fibroblast growth factor receptor 1	Show » « Hide Mutated genes in cancer Potential transmembrane proteins SPOCTOPUS predicted membrane proteins	Show » « Hide GO:0004713 [protein tyrosine kinase activity] GO:0005524 [ATP binding]	134	15.2	No	0
FGFR1-201	ENSP00000340636 ENST00000341462	P11362 Show all » « Hide P11362 [Direct mapping] Fibroblast growth factor receptor 1 D3DSX2 [Target identity:46%; Query identity:100%] Fibroblast growth factor receptor 1 (Fms-related tyrosine kinase 2, Pfeiffer syndrome), isoform CRA_b E9PN14 [Target identity:16%; Query identity:100%] Fibroblast growth factor receptor 1 C9J205 [Target identity:13%; Query identity:100%] Fibroblast growth factor receptor 1	Show » « Hide Kinases Tyr protein kinases CD markers Candidate cancer biomarkers Enzymes Transferases Mutated genes in cancer Potential transmembrane proteins Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins 1TM proteins predicted by MDM Potentially secreted proteins Secreted proteins predicted by MDSP SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000165 [MAPKKK cascade] GO:0001501 [skeletal system development] GO:0001525 [angiogenesis] GO:0001657 [ureteric bud development] GO:0001701 [in utero embryonic development] GO:0001759 [organ induction] GO:0001764 [neuron migration] GO:0001948 [glycoprotein binding] GO:0002053 [positive regulation of mesenchymal cell proliferation] GO:0002062 [chondrocyte differentiation] GO:0004713 [protein tyrosine kinase activity] GO:0005007 [fibroblast growth factor-activated receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral to plasma membrane] GO:0006351 [transcription, DNA-dependent] GO:0006355 [regulation of transcription, DNA-dependent] GO:0006468 [protein phosphorylation] GO:0007411 [axon guidance] GO:0007605 [sensory perception of sound] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0010518 [positive regulation of phospholipase activity] GO:0010863 [positive regulation of phospholipase C activity] GO:0010976 [positive regulation of neuron projection development] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase cascade] GO:0016021 [integral to membrane] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0016477 [cell migration] GO:0017134 [fibroblast growth factor binding] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019827 [stem cell maintenance] GO:0021837 [motogenic signaling involved in postnatal olfactory bulb interneuron migration] GO:0021847 [ventricular zone neuroblast division] GO:0021954 [central nervous system neuron development] GO:0030326 [embryonic limb morphogenesis] GO:0030901 [midbrain development] GO:0031175 [neuron projection development] GO:0035607 [fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development] GO:0042472 [inner ear morphogenesis] GO:0042473 [outer ear morphogenesis] GO:0042474 [middle ear morphogenesis] GO:0042803 [protein homodimerization activity] GO:0043009 [chordate embryonic development] GO:0043066 [negative regulation of apoptotic process] GO:0043406 [positive regulation of MAP kinase activity] GO:0043410 [positive regulation of MAPK cascade] GO:0045595 [regulation of cell differentiation] GO:0045666 [positive regulation of neuron differentiation] GO:0045668 [negative regulation of osteoblast differentiation] GO:0045787 [positive regulation of cell cycle] GO:0046777 [protein autophosphorylation] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0048339 [paraxial mesoderm development] GO:0048378 [regulation of lateral mesodermal cell fate specification] GO:0048469 [cell maturation] GO:0048705 [skeletal system morphogenesis] GO:0048762 [mesenchymal cell differentiation] GO:0050839 [cell adhesion molecule binding] GO:0051930 [regulation of sensory perception of pain] GO:0060045 [positive regulation of cardiac muscle cell proliferation] GO:0060117 [auditory receptor cell development] GO:0060445 [branching involved in salivary gland morphogenesis] GO:0060484 [lung-associated mesenchyme development] GO:0060665 [regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling] GO:0072091 [regulation of stem cell proliferation]	822	91.8	Yes	1
FGFR1-202	ENSP00000393312 ENST00000425967	P11362 Show all » « Hide P11362 [Direct mapping] Fibroblast growth factor receptor 1 D3DSX2 [Target identity:45%; Query identity:100%] Fibroblast growth factor receptor 1 (Fms-related tyrosine kinase 2, Pfeiffer syndrome), isoform CRA_b E9PN14 [Target identity:16%; Query identity:100%] Fibroblast growth factor receptor 1 C9J205 [Target identity:12%; Query identity:100%] Fibroblast growth factor receptor 1	Show » « Hide Kinases Tyr protein kinases CD markers Candidate cancer biomarkers Enzymes Transferases Mutated genes in cancer Potential transmembrane proteins Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins 1TM proteins predicted by MDM Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000165 [MAPKKK cascade] GO:0001501 [skeletal system development] GO:0001525 [angiogenesis] GO:0001657 [ureteric bud development] GO:0001701 [in utero embryonic development] GO:0001759 [organ induction] GO:0001764 [neuron migration] GO:0001948 [glycoprotein binding] GO:0002053 [positive regulation of mesenchymal cell proliferation] GO:0002062 [chondrocyte differentiation] GO:0004713 [protein tyrosine kinase activity] GO:0005007 [fibroblast growth factor-activated receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral to plasma membrane] GO:0006351 [transcription, DNA-dependent] GO:0006355 [regulation of transcription, DNA-dependent] GO:0006468 [protein phosphorylation] GO:0007411 [axon guidance] GO:0007420 [brain development] GO:0007435 [salivary gland morphogenesis] GO:0007605 [sensory perception of sound] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0010468 [regulation of gene expression] GO:0010518 [positive regulation of phospholipase activity] GO:0010552 [positive regulation of gene-specific transcription from RNA polymerase II promoter] GO:0010629 [negative regulation of gene expression] GO:0010863 [positive regulation of phospholipase C activity] GO:0010976 [positive regulation of neuron projection development] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase cascade] GO:0016021 [integral to membrane] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0016477 [cell migration] GO:0017134 [fibroblast growth factor binding] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019827 [stem cell maintenance] GO:0021769 [orbitofrontal cortex development] GO:0021837 [motogenic signaling involved in postnatal olfactory bulb interneuron migration] GO:0021847 [ventricular zone neuroblast division] GO:0021954 [central nervous system neuron development] GO:0030324 [lung development] GO:0030326 [embryonic limb morphogenesis] GO:0030901 [midbrain development] GO:0031175 [neuron projection development] GO:0035607 [fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development] GO:0042127 [regulation of cell proliferation] GO:0042472 [inner ear morphogenesis] GO:0042473 [outer ear morphogenesis] GO:0042474 [middle ear morphogenesis] GO:0042803 [protein homodimerization activity] GO:0043009 [chordate embryonic development] GO:0043066 [negative regulation of apoptotic process] GO:0043406 [positive regulation of MAP kinase activity] GO:0043410 [positive regulation of MAPK cascade] GO:0045595 [regulation of cell differentiation] GO:0045666 [positive regulation of neuron differentiation] GO:0045668 [negative regulation of osteoblast differentiation] GO:0045787 [positive regulation of cell cycle] GO:0046777 [protein autophosphorylation] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0048339 [paraxial mesoderm development] GO:0048378 [regulation of lateral mesodermal cell fate specification] GO:0048469 [cell maturation] GO:0048514 [blood vessel morphogenesis] GO:0048699 [generation of neurons] GO:0048705 [skeletal system morphogenesis] GO:0048762 [mesenchymal cell differentiation] GO:0050839 [cell adhesion molecule binding] GO:0051930 [regulation of sensory perception of pain] GO:0060045 [positive regulation of cardiac muscle cell proliferation] GO:0060117 [auditory receptor cell development] GO:0060445 [branching involved in salivary gland morphogenesis] GO:0060484 [lung-associated mesenchyme development] GO:0060665 [regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling] GO:0072091 [regulation of stem cell proliferation] GO:0090080 [positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway]	853	95.3	No	1
FGFR1-203	ENSP00000400162 ENST00000447712	P11362 Show all » « Hide P11362 [Direct mapping] Fibroblast growth factor receptor 1 D3DSX2 [Target identity:46%; Query identity:100%] Fibroblast growth factor receptor 1 (Fms-related tyrosine kinase 2, Pfeiffer syndrome), isoform CRA_b E9PNM3 [Target identity:36%; Query identity:100%] Fibroblast growth factor receptor 1 E9PN14 [Target identity:16%; Query identity:100%] Fibroblast growth factor receptor 1 C9J205 [Target identity:13%; Query identity:100%] Fibroblast growth factor receptor 1	Show » « Hide Kinases Tyr protein kinases CD markers Candidate cancer biomarkers Enzymes Transferases Mutated genes in cancer Potential transmembrane proteins Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins 1TM proteins predicted by MDM Potentially secreted proteins Secreted proteins predicted by MDSP SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000165 [MAPKKK cascade] GO:0001501 [skeletal system development] GO:0001525 [angiogenesis] GO:0001657 [ureteric bud development] GO:0001701 [in utero embryonic development] GO:0001759 [organ induction] GO:0001764 [neuron migration] GO:0001948 [glycoprotein binding] GO:0002053 [positive regulation of mesenchymal cell proliferation] GO:0002062 [chondrocyte differentiation] GO:0004713 [protein tyrosine kinase activity] GO:0005007 [fibroblast growth factor-activated receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral to plasma membrane] GO:0006351 [transcription, DNA-dependent] GO:0006355 [regulation of transcription, DNA-dependent] GO:0006468 [protein phosphorylation] GO:0007411 [axon guidance] GO:0007605 [sensory perception of sound] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0010518 [positive regulation of phospholipase activity] GO:0010863 [positive regulation of phospholipase C activity] GO:0010976 [positive regulation of neuron projection development] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase cascade] GO:0016021 [integral to membrane] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0016477 [cell migration] GO:0017134 [fibroblast growth factor binding] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019827 [stem cell maintenance] GO:0021837 [motogenic signaling involved in postnatal olfactory bulb interneuron migration] GO:0021847 [ventricular zone neuroblast division] GO:0021954 [central nervous system neuron development] GO:0030326 [embryonic limb morphogenesis] GO:0030901 [midbrain development] GO:0031175 [neuron projection development] GO:0035607 [fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development] GO:0042472 [inner ear morphogenesis] GO:0042473 [outer ear morphogenesis] GO:0042474 [middle ear morphogenesis] GO:0042803 [protein homodimerization activity] GO:0043009 [chordate embryonic development] GO:0043066 [negative regulation of apoptotic process] GO:0043406 [positive regulation of MAP kinase activity] GO:0043410 [positive regulation of MAPK cascade] GO:0045595 [regulation of cell differentiation] GO:0045666 [positive regulation of neuron differentiation] GO:0045668 [negative regulation of osteoblast differentiation] GO:0045787 [positive regulation of cell cycle] GO:0046777 [protein autophosphorylation] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0048339 [paraxial mesoderm development] GO:0048378 [regulation of lateral mesodermal cell fate specification] GO:0048469 [cell maturation] GO:0048705 [skeletal system morphogenesis] GO:0048762 [mesenchymal cell differentiation] GO:0050839 [cell adhesion molecule binding] GO:0051930 [regulation of sensory perception of pain] GO:0060045 [positive regulation of cardiac muscle cell proliferation] GO:0060117 [auditory receptor cell development] GO:0060445 [branching involved in salivary gland morphogenesis] GO:0060484 [lung-associated mesenchyme development] GO:0060665 [regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling] GO:0072091 [regulation of stem cell proliferation]	822	91.9	Yes	1

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.