ITGA8

GENE INFORMATION

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Gene name

ITGA8

Synonyms

Description

Integrin, alpha 8 (HGNC Symbol)

Entrez gene summary

Integrins are heterodimeric transmembrane receptor proteins that mediate numerous cellular processes including cell adhesion, cytoskeletal rearrangement, and activation of cell signaling pathways. Integrins are composed of alpha and beta subunits. This gene encodes the alpha 8 subunit of the heterodimeric integrin alpha8beta1 protein. The encoded protein is a single-pass type 1 membrane protein that contains multiple FG-GAP repeats. This repeat is predicted to fold into a beta propeller structure. This gene regulates the recruitment of mesenchymal cells into epithelial structures, mediates cell-cell interactions, and regulates neurite outgrowth of sensory and motor neurons. The integrin alpha8beta1 protein thus plays an important role in wound-healing and organogenesis. Mutations in this gene have been associated with renal hypodysplasia/aplasia-1 (RHDA1) and with several animal models of chronic kidney disease. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2014]

Chromosome

10

Cytoband

p13

Chromosome location (bp)

15555948 - 15762124

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000077943 (version 75.37)

Entrez gene

8516

UniProt

P53708 (UniProt - Evidence at protein level)

neXtProt

NX_P53708

Antibodypedia

ITGA8 antibodies
 

PROTEIN VIEW

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ITGA8-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ITGA8-001 ENSP00000367316
ENST00000378076
P53708
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